A5103233512- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- Cytomegalovirus and herpesvirus research
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Immune cells in cancer
- Autism Spectrum Disorder Research
- Immune Cell Function and Interaction
- Cancer-related gene regulation
University of Exeter
2024
Asthma UK
2018-2021
King's College London
2018-2021
Abstract GATA3 is as a lineage-specific transcription factor that drives the differentiation of CD4 + T helper 2 (Th2) cells, but also involved in variety processes such immune regulation, proliferation and maintenance other cell non-T lineages. Here we show mechanism utilised by cells to increase mitochondrial mass response DNA damage through actions AMPK. Activated AMPK increases expression PPARG coactivator 1 alpha ( PPARGC1A or PGC1α protein) at level translation, while enhances nuclear...
Abstract Loss-of-function mutations in genes encoding lysine methyltransferases (KMTs) and demethylases (KDMs) responsible for regulating the trimethylation of histone 3 on 4 (H3K4me3) are associated with neurodevelopmental conditions, including autism spectrum disorder intellectual disability. To study specific role H3K4me3 demethylation, we investigated phenotypes mice without KDM5B demethylase activity. These exhibited autism-like behaviours increased brain size. levels expression were...
Introductory paragraph GATA binding protein 3 (GATA3) has traditionally been regarded as a lineage-specific transcription factor that drives the differentiation of CD4 + T helper (Th) 2 cells. However, increasing evidence shows GATA3 is involved in myriad processes such immune regulation, proliferation and maintenance other cell non-T lineages. We show here previously unknown mechanism utilized by cells to increase mitochondrial mass response DNA damage through GATA3, AMP-activated kinase...