A5013749903- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Colorectal and Anal Carcinomas
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Genetic Associations and Epidemiology
- Colorectal Cancer Screening and Detection
- Tumors and Oncological Cases
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Gastrointestinal Tumor Research and Treatment
- Teratomas and Epidermoid Cysts
Zhengzhou University
2024
Johns Hopkins University
2024
Genetic studies of nontraditional glycemic biomarkers, glycated albumin and fructosamine, can shed light on unknown aspects type 2 diabetes genetics biology. We performed a multiphenotype genome-wide association study fructosamine from 7,395 White 2,016 Black participants in the Atherosclerosis Risk Communities (ARIC) common variants genotyped/imputed data. discovered two significant loci, one mapping to known gene (ARAP1/STARD10) another novel region (UGT1A complex genes), using multiomics...
Background: Microsatellite instability-high (MSI-H) is an important biomarker for predicting the effects of immune checkpoint inhibitors (ICIs) in colorectal cancer (CRC) patients. However, due to low mutation rate MSI-H/deficient mismatch repair (dMMR) overall population, some doctors are view that testing this indicator increases burden on patients, and consequently patients fail receive most beneficial treatment methods. In order provide criteria younger with a higher proportion MSI-H, we...
Changzheng Li, Zhenyu Jiachen Zhang, Xijie Matthew Yuan-Kun Wei, Nan Zun Teo, Pengfei Ma, Junli Sen Zhi Yuzhou Zhao
Background: Pelvic malignant tumors often originate in the rectum, bladder, uterus, and other organs. In patients with locally advanced tumours presence of direct invasion one or more organs, negative tumor resection margin (R0) can be very beneficial to patient survival if it performed. As a multidisciplinary high-risk surgical method, pelvic exenteration (PE) procedure has only been reported few medical centres internationally. We retrospectively analyzed clinical data who had undergone PE...
Background: For patients who need laparoscopic radical gastrectomy, lymph node dissection (LND) and optimization of surgical procedures are particularly important. This study introduces the "quadrant-sandwich" method in clockwise modular D2 LND evaluates advantages safety this method. Methods: The clinical data 108 total gastrectomy admitted to Affiliated Cancer Hospital Zhengzhou University from January 2019 2022 were retrospectively analyzed. Based on different processes, 55 allocated...
目的： 探讨食管全系膜切除在食管胃结合部腺癌（AEG）根治术中的安全性和疗效。 方法： 采用回顾性队列研究方法，分析2016年6月至2019年1月期间，于河南省肿瘤医院（郑州大学附属肿瘤医院）普通外科经膈肌裂孔或左侧胸腹联合入路行根治性手术切除的、术前诊断食管受累≥1 cm的95例AEG腺癌患者的临床病例资料。依据手术方式分为全系膜切除组（33例）和传统手术组（62例）。比较两组患者的临床病例资料及近期疗效，包括手术时间、术中出血量、术后住院时间、术后并发症、术后30 d内病死率、上切缘长度以及淋巴结获取情况方面的差异。 结果：...
目的： 探讨SiewertⅡ型食管胃结合部腺癌新辅助化疗前经内镜注射纳米碳标记肿瘤上界预切点及淋巴示踪的临床意义。 方法： 采用回顾性队列研究方法。分析2017年6月至2020年6月期间，河南省肿瘤医院接受新辅助化疗并行D(2)根治术的81例SiewertⅡ型食管胃结合部腺癌患者临床资料，根据新辅助化疗前是否在内镜下应用纳米碳淋巴示踪技术，将全组患者分为纳米碳示踪组（39例）和常规手术组（42例）。观察两组的手术情况、上切缘长度及淋巴结获取情况。 结果： 两组患者手术时间、术中出血量的差异无统计学意义（均P>0.05）。纳米碳示踪组食管上切缘长度长于常规手术组，差异有统计学意义[（3.8±0.5）cm比（2.8±0.5）cm，t=8.696，P 0.05）。 结论： SiewertⅡ型食管胃结合部腺癌新辅助化疗前经内镜注射纳米碳淋巴示踪剂标记肿瘤上界预切点及淋巴示踪安全、可行、有效。.