A5036713963- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Histiocytic Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Iron Metabolism and Disorders
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Monoclonal and Polyclonal Antibodies Research
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Autoimmune and Inflammatory Disorders Research
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Renal and related cancers
- Complement system in diseases
- Neuroblastoma Research and Treatments
- Ubiquitin and proteasome pathways
- Soil Mechanics and Vehicle Dynamics
- Agricultural Engineering and Mechanization
- Cytokine Signaling Pathways and Interactions
- Kawasaki Disease and Coronary Complications
- Methemoglobinemia and Tumor Lysis Syndrome
- Image Processing Techniques and Applications
Sichuan University
2016-2025
Henan University of Technology
2023-2025
West China Second University Hospital of Sichuan University
2016-2025
King's College London
2024
Yangzhou University
2014-2024
Northern Jiangsu People's Hospital
2024
Beijing University of Technology
2024
Pediatrics and Genetics
2024
Soochow University
2024
Second Hospital of Liaohe Oilfield
2023
<h3>Importance</h3> A randomized clinical trial is needed to determine whether the second-generation Abl–tyrosine kinase inhibitor dasatinib more effective than first-generation imatinib mesylate for childhood Philadelphia chromosome–positive acute lymphoblastic leukemia (ALL). <h3>Objective</h3> To given at a daily dosage of 80 mg/m<sup>2</sup>is 300 mg/m<sup>2</sup>to improve event-free survival children with ALL in context intensive chemotherapy without prophylactic cranial irradiation....
Acute lymphoblastic leukemia (ALL) is the most common malignancy among children. The trial Chinese Children Leukemia Group (CCLG)‐ALL 2008 was a prospective clinical designed to improve treatment outcome of childhood ALL through first nation‐wide collaborative study in China. Totally 2231 patients were recruited from ten tertiary hospitals eight cities. stratified according clinical‐biological characteristics and early response. Standard risk (SR) intermediate (IR) groups treated with...
Abstract Background Glucocorticoid (GC) resistance is frequently seen in acute lymphoblastic leukemia of T-cell lineage (T-ALL). In this study we investigate the potential and mechanism using rapamycin to restore sensitivity GC-resistant T-ALL cells dexamethasone (Dex) treatment. Methods Cell proliferation was detected by 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) assay. Fluorescence-activated cell sorting (FACS) analysis used analyze apoptosis cycles. Western blot...
Abstract The present study was designed to detect three single nucleotide polymorphisms (SNPs) located on 22q11 that thought as being of particularly importance for genetic research into schizophrenia. We recruited a total 176 Chinese family trios Han descent, consisting mothers, fathers and affected offspring with schizophrenia the analysis. transmission disequilibrium test (TDT) showed SNPs, rs10314 in 3′-untranslated region CLDN5 locus associated ( χ 2 = 4.75, P 0.029). other two...
Human interleukin 1 beta (IL-1 beta) exerts its diverse biological effects by binding to specific receptors on target cells. Two types of IL-1 receptor (IL-1R) have been identified: the type I IL-1R (p80) and II (p68). Using site-specific mutagenesis, we identified site for murine IL-1R. Analogs protein containing defined amino acid substitutions were produced tested competitive two IL-1Rs. Substitutions acids at seven positions resulted in analogs that had greater than or equal 100-fold...
Traumatic brain injury (TBI) can lead to short-term and long-term physical cognitive impairments, which have significant impacts on patients, families, society. Currently, treatment outcomes for this disease are often unsatisfactory, due at least in part the fact that molecular mechanisms underlying development of TBI largely unknown. Here, we observed upregulation Piezo2, a key mechanosensitive ion channel protein, injured tissue mouse model induced by controlled cortical impact....
Langerhans cell histiocytosis (LCH) is characterized genetically by diverse gene mutations of the mitogen-activated protein kinase signaling cascade. BRAF N486_T491delinsK mutation a rare that involves β2-αC ring domain, causing activation pathway, and predicted to be resistant chemotherapy V600E inhibitor in adult LCH cases. Here, we report childhood case with this novel had good response conventional chemotherapy. This suggests children might differ from counterparts terms clinical...
The present work measured circulating antibodies against native gliadins, deamidated gliadin–derived epitopes, and transglutaminase 2 (TGM2) in 473 patients with schizophrenia 478 control subjects among a Chinese population. results showed that 27.1% of were positive for the IgA antibody gliadins compared 17.8% (χ2 = 11.52, P .0007, OR 1.72, 95% CI 1.25–2.35), although this significant difference appeared to be due mainly low gliadin levels female controls. A total 27.6% 13.9% controls...
Wheat is prone to insect infestations during harvesting, transportation, and storage, leading heat, mold, deterioration. Timely pest detection vital for effective prevention improved storage quality. Traditional methods, such as manual identification biological information detection, have limitations, including low efficiency, grain damage, difficulty in identifying larvae. This study proposed a method detecting Sitophilus zeamais (S. zeamais) the interior of wheat based on computed...
Increasing evidence indicates that rapamycin could be used as a potential glucocorticoid (GC) sensitizer in lymphoblastic malignancies via genetic prevention of 4E-BP1 phosphorylation. Interestingly, we found combined with dexamethasone can effectively reverse GC resistance null lymphoma cells. In this study, investigated the link between mTOR/p70S6K signaling pathway, glycolysis, autophagy and resistance.Antitumor effects combination were evaluated on cell viability by MTT assay vivo...
Ciclopirox olamine (CPX) is an antifungal drug that has been reported to have antitumor effects. In this study we investigated the antileukemia effects and possible mechanisms of CPX on glucocorticoid (GC)-resistant T-cell acute lymphoblastic leukemia (T-ALL) cell lines. The results indicated inhibited growth GC-resistant T-ALL cells in a time- dose-dependent manner, effect was closely correlated with downregulation intracellular ferritin. induced cycle arrest at G1 phase by upregulation...
// Ling Gu 1, * , Zhihui Yi 2, Yanle Zhang 1 Zhigui Ma Yiping Zhu Ju Gao Laboratory of Hematology/Oncology, Department Pediatric Key Birth Defects and Related Diseases Women Children, Ministry Education, West China Second University Hospital, Sichuan University, Chengdu, 2 Gastroenterology, These authors contributed equally to this work should be considered co-first Correspondence to: Gu, email: guling00@163.com Keywords: 2-deoxy-D-glucose, glycolysis, glucocorticoid resistance, acute...
Background This study aimed to understand the clinical characteristics and outcomes of children with Langerhans cell histiocytosis (LCH) in China.Methods We conducted a retrospective 95 paediatric patients LCH West China Second University Hospital Sichuan between July 2013 August 2020.Results The onset age multisystem (MS-LCH) risk organ (RO) involvement was younger than that MS-LCH without RO (p = .002) single system < .001) patients; bone most frequently involved organ, followed by skin....
Moldy corn produces aflatoxin and gibberellin, which can have adverse effects on human health if consumed. Mold is a significant factor that affects the safe storage of corn. If not detected controlled in timely manner, it will result substantial food losses. Understanding infection patterns mold kernels changing characteristics internal structure after crucial for guiding innovation optimizing detection methods moldy This knowledge also helps maintain ensure safety. study was based X-ray...