A5064917918- Neurogenetic and Muscular Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- Spinal Dysraphism and Malformations
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Higher Education Governance and Development
- Regional Development and Policy
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Zebrafish Biomedical Research Applications
Columbia University
2017-2023
Eli Lilly (United States)
2023
Highlights•C1q refines spinal sensory-motor circuits during normal development•Upregulated C1q tags SMA synapses for elimination via classical cascade and microglia•Pharmacological inhibition of or depletion microglia confer benefit in mice•C1q deletion results an excessive number synapses, leading to behavioral deficitsSummaryMovement is essential behavior requiring the assembly refinement motor circuits. However, mechanisms responsible circuit synapse maintenance are poorly understood....
B cells contribute to multiple aspects of autoimmune disorders, and cell-targeting therapies, including cell depletion, have been proven be efficacious in treatment diseases. However, the development novel therapies targeting with higher efficacy a nondepleting mechanism action is highly desirable. Here we describe nondepleting, high-affinity anti-human CD19 antibody LY3541860 that exhibits potent inhibitory activities. inhibits activation, proliferation, differentiation primary human high...
Neuromodulation by serotonin regulates the activity of neuronal networks responsible for a wide variety essential behaviours. Serotonin (or 5-HT) typically activates metabotropic G protein-coupled receptors, which in turn initiate second messenger signalling cascades and induce short long-lasting behavioural effects. is intricately involved production locomotor gait control different motor Although dysfunction serotonergic neurotransmission has been associated with mood disorders spasticity...