A5103764707- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood properties and coagulation
- Cancer-related gene regulation
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Hepatitis C virus research
- Neonatal Health and Biochemistry
- Blood groups and transfusion
- Hip disorders and treatments
- Hematological disorders and diagnostics
- Platelet Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Kawasaki Disease and Coronary Complications
- Healthcare Policy and Management
- Muscle and Compartmental Disorders
- Cardiovascular Conditions and Treatments
- Syphilis Diagnosis and Treatment
- Neurogenetic and Muscular Disorders Research
- Diabetes Management and Research
- Autoimmune and Inflammatory Disorders Research
- Parvovirus B19 Infection Studies
Royal College of Surgeons of England
2025
Mayne Pharma (Australia)
2018
University of Ulster
1970-2000
Royal Victoria Hospital
1980-2000
Victoria Hospital
2000
Royal Victoria Hospital
1985-1998
Royal Cornwall Hospital
1996
Queen Elizabeth Hospital Birmingham
1994
Royal Victoria Eye and Ear Hospital
1969-1993
Belfast City Hospital
1970
International guidelines recommend treatment intensification combining docetaxel or androgen receptor pathway inhibitors with deprivation therapy for metastatic hormone-sensitive prostate cancer (mHSPC). However, evidence suggests underuse in many high-income countries. This study evaluates the use of English National Health Service (NHS) and explores patient hospital-level factors associated variation. All men diagnosed mHSPC England between January 2018 December 2022 were identified...
Recent reports have suggested an association between Perthes’ disease and underlying thrombophilic or hypofibrinolytic tendency. In Northern Ireland there is a high incidence of (11.7 per 100 000 1 in 607 children) stable paediatric population. We reviewed 139 children with compared them control group 220 aged- gender-matched healthy primary schoolchildren similar racial ethnic backgrounds. There were no significant deficiencies antithrombotic factors protein C, S, antithrombin III...
Recent reports have suggested an association between Perthes' disease and underlying thrombophilic or hypofibrinolytic tendency. In Northern Ireland there is a high incidence of (11.7 per 100,000 1 in 607 children) stable paediatric population. We reviewed 139 children with compared them control group 220 aged- gender-matched healthy primary schoolchildren similar racial ethnic backgrounds. There were no significant deficiencies antithrombotic factors protein C, S, antithrombin III...
The investigation of a 33 year old man with lifelong bleeding tendency is described. Defective fibrinolysis was suspected in 1968, when clinical corrected by administration aminocaproic acid. paper establishes the diagnosis as alpha 2-antiplasmin deficiency and describes its management oral tranexamic
Antithrombin III, factor VIII, fibrinogen and fribrinolytic activity were measured in two groups of long-standing insulin-dependent diabetic subjects (24 with proliferative retinopathy, 24 without detectable retinopathy) non-diabetic controls. Mean antithrombin III ( ± 1 SD) was 115.9 15.1), 109.8 18.1) 101.4% 12.5), respectively, the non-retinopathy control groups. Statistical significance obtained when comparing retinopathy (p < 0.001) all 48 diabetics collectively controls 0.01). VIII...
A 28‐year‐old man who had suffered from erythropoietic protoporphyria since infancy was referred because of worsening photosensitivity. Conventional therapy with β‐carotene, terfenadine and topical sunscreens ineffective or not tolerated, he treated transfusions washed packed cells. Unexpectedly, his photosensitivity deteriorated further, whole blood protoporphyrin levels doubled developed abnormal liver function tests. This is the first report such an adverse response to transfusion for may...
Thrombosis and Disseminated Intravascular Coagulation following Treatment with the Prothrombin C Complex Concentrate, DEFIX -
Lymphoblastic transformation of polycythaemia rubra vera is an extremely rare phenomenon. A case a 76 year old man with who developed acute lymphoblastic leukaemia (ALL) 16 years after his initial diagnosis reported. Membrane markers showed CD10 positive (common ALL) immunophenotype. To our knowledge this association has not been previously recorded. The occurrence ALL in may indicate that minority patients clonal expansion abnormal pluripotent haemopoietic stem cell responsible for the...
We report the case of a 26‐year‐old man with haemophilia B and human immunodeficiency virus infection (HIV) who presented short history multiple dermatofibromas. He also had troublesome psoriasis for which he was receiving acitretin UVB therapy recently discontinued low‐dose daily prednisolone associated arthropathy. Multiple dermatofibromas are rare have been reported previously in association autoimmune disease, especially individuals immunosuppressive therapy. believe this to be first an...
<h3>Objective</h3> To determine the short- and midterm outcome of arterial switch operation (ASO) in infants with normal abnormal coronary artery patterns. <h3>Methods</h3> A retrospective analysis was conducted experience ASO at one institution over span 20 years from 1985 through 2005. Two hundred eight consecutive ASOs were performed by same surgeon for transposition double-outlet ventricle complexes. Of 208 patterns, 159 (76%) 49 (24%) abnormal, respectively. These classified into 4...
Summary. To assess the viral safety of Scottish National Blood Transfusion Service (SNBTS) intermediate purity factor VIII and IX concentrates, liver function status were assessed prospectively in 13 recipients. None developed hepatitis or seroconverted to HIV HCV. This study provides additional evidence for efficacy dry heat treatment at 80°C 72 h preventing virus transmission by coagulation concentrates.
(1998). Familial Hemolytic Anemia Due to Hb Sabine [β91(F7)Leu←Pro] Identified BY Polymerase Chain Reaction. Hemoglobin: Vol. 22, No. 3, pp. 263-266.
The prevalence of the alternative alleles an unusual length polymorphism in promoter human antithrombin III (AT3) gene was determined a sample 155 unrelated individuals from Northern Irish population. 108bp L allele and 32bp S occurred at frequencies 0.21 0.79 respectively. Some homology noted between L-specific sequence region immediately downstream. Residual also evident sequences, suggesting that derived during evolution by partial deletion followed divergence. functional significance...
SUMMARY. An ion‐exchange chromatography purified factor VIII concentrate (Liberate) that had undergone a solvent—detergent viral inactivation treatment was compared with an intermediate‐purity (Z8), which terminally heated at 80°C for 72 h, in 15 haemophilia A patients blinded crossover pharmacokinetic study. Both products achieved peak level close to predicted (100IU/dl Liberate and 103IU/dl Z8) there were no significant differences the recoveries nor of any other parameters. We conclude...