A5008380469- Biochemical Acid Research Studies
- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Catalysis for Biomass Conversion
- Atomic and Subatomic Physics Research
- Steroid Chemistry and Biochemistry
- Synthetic Organic Chemistry Methods
- Microbial metabolism and enzyme function
- Carbon dioxide utilization in catalysis
- Diet, Metabolism, and Disease
- Inhalation and Respiratory Drug Delivery
- Enzyme Structure and Function
- Quantum, superfluid, helium dynamics
- biodegradable polymer synthesis and properties
- Amino Acid Enzymes and Metabolism
- Biofuel production and bioconversion
- Cyclopropane Reaction Mechanisms
Institut de Chimie de Clermont-Ferrand
2022-2024
Université Clermont Auvergne
2022-2024
Centre National de la Recherche Scientifique
2012-2024
Center for MathematicaL studies and their Applications
2012
École Polytechnique
2012
Transketolase variants catalyse a promiscuous acyloin condensation of aliphatic aldehydes leading in one step to unsymmetrical α-hydroxyketones while offering green advances compared previous enzymatic and chemical ways.
Abstract We described a strategy for the enzymatic synthesis of 1‐deoxy and 1,2‐deoxyketoses from aliphatic α‐ketoacids, pyruvate 2‐oxobutyrate, as donors natural aldoses variable chain length acceptors, catalyzed by thermostable transketolase variants Geobacillus stearothermophilus (TK gst ). Analytical studies have been carried out on panel TK with appropriate substrates allowing to select best combinations apply it preparative scale obtained good excellent isolated yields (61%–86%). To...
A sustainable, convenient, scalable, one‐step method for the two‐carbon chain elongation of cheap and biomass‐derived pentoses (l‐arabinose, 2‐deoxy‐d‐ribose) hexose l‐rhamnose was developed to produce Cn+2 deoxy ketoses (C‐7 C‐8) using transketolase, an enzyme catalyzing quasi‐irreversible transfer a ketol group from α‐keto acid aldehyde. Deoxygenated ‐ commonly obtained by chemical synthesis were afforded through suitable combination both nucleophile electrophile substrates in presence...