A5093817851- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Bioinformatics and Genomic Networks
- DNA and Nucleic Acid Chemistry
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Radiomics and Machine Learning in Medical Imaging
- RNA and protein synthesis mechanisms
- Gene expression and cancer classification
The University of Texas at Austin
2024
Abstract In contrast to cancer driver gene alterations, genes with alterations occurring frequently together are unlikely play a direct role in tumor development, and more likely contribute normal cellular functions necessary for the ongoing maintenance survival of tumor, most robust these preserved across model systems. We introduce two molecular signature-centric methods, RECO (recurring co-occurring) Crosstalk, identify sets characterized by that occur sample Our overall approach builds...
Introduction: The demand for comprehensive data resources has surged due to advancements in research aimed at tackling complex questions. Data integration techniques have evolved significantly, moving from the of various omics types a single patient multimodal leveraging machine and transfer learning. This evolution given rise concept digital twins facilitate silico prediction treatment response. Furthermore, emergence fusion fabric concepts highlights growing need broader connectivity,...
ABSTRACT The technology of Triplex-forming oligonucleotides (TFOs) provides an approach to manipulate genes at the DNA level. TFOs bind specific sites on genomic DNA, creating a unique intermolecular triple-helix structure through Hoogsteen hydrogen bonding. This targeting by is site-specific and locations are referred as TFO target (TTS). Triplexes have been observed selectively influence gene expression, homologous recombination, mutations, protein binding, damage. These typically feature...
Abstract The technology of triplex-forming oligonucleotides (TFOs) provides an approach to manipulate genes at the DNA level. TFOs bind specific sites on genomic DNA, creating a unique intermolecular triple-helix structure through Hoogsteen hydrogen bonding. This targeting by is site-specific and locations are referred as TFO target (TTS). Triplexes have been observed selectively influence gene expression, homologous recombination, mutations, protein binding, damage. These typically feature...