A5071502849- Advancements in Battery Materials
- Fiber-reinforced polymer composites
- Graphene research and applications
- Advanced Battery Technologies Research
- Advanced Battery Materials and Technologies
- Acute Myeloid Leukemia Research
- Electron and X-Ray Spectroscopy Techniques
- Epigenetics and DNA Methylation
- Fuel Cells and Related Materials
- Electrochemical Analysis and Applications
- Electrocatalysts for Energy Conversion
- Aerodynamics and Fluid Dynamics Research
- Conducting polymers and applications
- Semiconductor materials and interfaces
- Semiconductor materials and devices
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Ion-surface interactions and analysis
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Nuclear physics research studies
- Graphite, nuclear technology, radiation studies
Kyoto University
2018-2023
Toyota Motor Corporation (Japan)
2008-2023
Takeda (Japan)
2017-2019
Abstract Lysine-specific demethylase 1A (LSD1, KDM1A) specifically demethylates di- and monomethylated histones H3K4 K9, resulting in context-dependent transcriptional repression or activation. We previously identified an irreversible LSD1 inhibitor T-3775440, which exerts antileukemic activities a subset of acute myeloid leukemia (AML) cell lines by inducing transdifferentiation. The NEDD8-activating enzyme pevonedistat (MLN4924, TAK-924) is investigational drug with antiproliferative AML,...
Since the commercialization of rechargeable Li ion batteries in early 1990 s, performance these devices has continually improved. In such batteries, graphite is typically used as negative electrode and present work examined reaction mechanisms at electrodes based on operando synchrotron X-ray diffraction analyses during charge/discharge. The resulting in-plane patterns Li-intercalated permitted a detailed analysis changes three-dimensional structure electrode. As intercalation proceeded from...
The charge/discharge reaction mechanisms of graphite negative electrodes in Li ion batteries were investigated via operando synchrotron X-ray diffraction at 0 °C and 25 °C. intercalation ions formed the stage 1 compound with an in-plane structure LiC 6 ; while only 2, structures 9 . degree expansion a, b -axes c -axis directions by was less than that Hence, it difficult to form further increases concentration, charging low temperature became difficult. De-intercalation did not follow...
Turbostratic carbon graphitized at ca. 2000 °C exhibits low discharge capacity but excellent pulse charge/discharge characteristics and long cycle performance. In this study, to clarify the mechanism, intercalation process of Li into turbostratic graphite was investigated by operando synchrotron X-ray diffraction 7 Li-NMR spectroscopy. The dataset obtained from both methods synchronously analyzed treating it as a function LiC x composition estimated curves. It found that profile spectrum...
Li-ion batteries require quantitative analysis of the crystal structure change in graphite electrode during charge/discharge reactions to improve their performance. Herein, we investigated thermodynamically stable phases LixC6 and transitions by first-principles free-energy calculations including vibrational free energy configurational entropy. We considered in-plane configurations six structures with different Li concentrations layer interlayer AA, AB, mixed stacks for eight stages. The...
The first preparation of Li-graphite intercalation compound (Li-GIC) was attempted by Hérold et al. in 1955. Since then, a lot reports have been made mainly the research groups France, and with regard to stage I II compounds, it is clarified that they take in-plane structures called P(√3×√3)R30°. Though there many since 1970s, detail discussion has not done so far concerning mechanism structure higher compounds. reason concentration Li species becomes smaller stages. second strong preferred...
Introduction : In order to promote development of electric vehicle, it is required improve the capacity density a battery, battery performance at low temperature, and high rate property battery. Characterization size distribution average carbon in negative electrode significantly influence on performance. We have studied clarification graphitic carbon’s properties influencing LIB especially temperature. Firstly, X-ray diffraction profiles several carbons were analyzed by fundamental...
Introduction : In order to promote development of electric vehicle, it is required improve the capacity density, low-temperature performance, and high-rate property batteries. Understanding lithium intercalation de-intercalation mechanism at graphite electrode storage battery (LIB) very important for this purpose. Crystal structure changes lithium-intercalated during charge discharge processes were investigated by operando X-ray diffraction (XRD) measurements using a synchrotron radiation...
Introduction The rechargeable Li-ion battery (LIB) is a successful energy storage device because of its high density and long cycle life. In order to improve performance, quantitative understanding elementary reactions in the LIB such as reaction Li intercalation from electrolyte solution into graphite crystal structure change during must be great help. Structure Li-intercalated charge/discharge processes was recently observed by operando X-ray diffraction measurements using synchrotron...