A5082766868- Anesthesia and Sedative Agents
- Mechanical Circulatory Support Devices
- Anesthesia and Pain Management
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Anesthesia and Neurotoxicity Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Pediatric Pain Management Techniques
- Inflammatory Bowel Disease
- Diabetes and associated disorders
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- COVID-19 and healthcare impacts
- Thermal Regulation in Medicine
- Heart Failure Treatment and Management
- Hemodynamic Monitoring and Therapy
- Foreign Body Medical Cases
- Intramuscular injections and effects
Royal Brompton & Harefield NHS Foundation Trust
2018-2024
Guy's and St Thomas' NHS Foundation Trust
2024
Harefield Hospital
2021-2024
Royal Brompton Hospital
2016-2021
Intensive Care Society
2020
Imperial College London
2020
Policlinico Umberto I
2001-2016
Sapienza University of Rome
1999-2015
Boston Children's Hospital
2005
Ospedale di Cattinara
1998
Rationale: Clinical and epidemiologic data in coronavirus disease (COVID-19) have accrued rapidly since the outbreak, but few address underlying pathophysiology.Objectives: To ascertain physiologic, hematologic, imaging basis of lung injury severe COVID-19 pneumonia.Methods: Clinical, laboratory were collated. Radiologic (computed tomography (CT) pulmonary angiography [n = 39] dual-energy CT [DECT, n 20]) studies evaluated: observers quantified patterns (including extent abnormal presence...
Oral premedication is widely used in pediatric anesthesia to reduce preoperative anxiety and ensure smooth induction. Midazolam currently the most commonly premedicant, but good results have also been reported with clonidine. The aim of present study was compare clinical effects oral midazolam clonidine.We performed a prospective open 64 children who were randomly assigned receive either 0.5 mg.kg (-1) (group M) or clonidine 4 microg.kg C) prior mask Drug acceptance, sedation anxiolysis,...
A significant proportion of patients with COVID-19 develop acute respiratory distress syndrome (ARDS) high risk death. The efficacy veno-venous extracorporeal membrane oxygenation (VV-ECMO) for on longer-term outcomes, unlike in other viral pneumonias, is unknown. In this study, we aimed to compare the 6 month mortality receiving VV-ECMO support a historical ARDS cohort. Fifty-three consecutive admitted Royal Brompton Hospital between March 17, 2020 and May 30, were identified. Mortality,...
To ascertain: 1) the frequency of thrombocytopenia and heparin-induced thrombocytopenia; 2) positive predictive value Pretest Probability Score in identifying 3) clinical outcome adult patients receiving venovenous- or venoarterial-extracorporeal membrane oxygenation, compared with cardiopulmonary bypass.A single-center, retrospective, observational cohort study from January 2016 to April 2018.Tertiary referral center for cardiac respiratory failure.Patients who received extracorporeal...
Summary Background: Clonidine premedication in children reliably provides preoperative sedation and anxiolysis, but onset of oral clonidine is known to be slow. Nasal has been shown reach peak plasma levels within 10 min rodents. The aim the present study was compare clinical effects percentage steal‐induction after by nasal route. Methods: Forty children, aged 1–6 years, scheduled for minor infraumbilical surgery, were randomly assigned receive either pure 4 μg·kg −1 intranasally (group CN,...
Summary Background: The aim of the present pilot study was to compare analgesic efficacy S(+)‐ketamine either alone or in combination with neostigmine for caudal blockade pediatric surgery. Methods: A total 40 children were randomly assigned receive after induction general anesthesia 1 mg·kg −1 (group K, n = 20) S (+)‐ketamine 0.5 plus 10 μ g·kg KN, 20). Anesthesia maintained sevoflurane and a laryngeal mask airway (LMA TM ), no additional analgesics administered. Postoperative pain sedation...
Summary Objectives/Aims To investigate whether melatonin would be an alternative drug to clonidine for performance of steal induction. Background Distress during induction might have a negative impact on postoperative behavior. A is technique smooth anesthesia induction, and has been the primary agent this purpose. There are conflicting results regarding efficacy premedication, but its sleep inducing properties shown in children. Methods Pediatric patients ASA I II were randomly assigned...
Summary Background: The aim of this study was to evaluate postoperative analgesia provided by caudal S(+)‐ketamine and plus clonidine without local anesthetic. Methods : Forty‐four children aged 1–5 years consecutively scheduled for inguinal hernia repair, hydrocele repair or orchidopexy were randomly assigned receive a injection either 1 mg·kg −1 (group K) 0.5 μ g·kg KC). Postoperative sedation evaluated CHEOPS Ramsay scale from emergence general anesthesia 24 h. Results No statistical...
The alpha2 agonist clonidine has become a popular drug for premedication in children. Effects and pharmacokinetics after oral, rectal, intravenous administration are well known. aim of this study was to investigate the absorption nasal drops children.Thirteen ASA I pediatric patients received induction anesthesia 4 mcg x kg(-1) by route. Blood samples were taken during 12-h period plasma levels analyzed liquid chromatography-mass spectrometry. Data calculated computer-aided curve-fitting...
Summary Background: The CobraPLA TM is a new supraglottic airway device designed for the use in spontaneously breathing and mechanically ventilated patients. In adults it has been found as effective LMA, but with better sealing qualities. aim of present study was to evaluate fit characteristics size 1.5 2 children. Methods: Forty children, ASA I/II, aged 1–10 years, weighing 10–35 kg were scheduled minor surgical procedures. number attempts insertion fiberoptic positioning assessed. After...
Introduction In healthcare teams, psychological safety is associated with improved performance, communication, collaboration and patient safety. Extracorporeal membrane oxygenation (ECMO) retrieval teams are multidisciplinary that initiate ECMO therapy for patients severe acute respiratory failure in referring hospitals transfer to regional specialised centres ongoing care. The present study aimed explore an team’s experience of generate recommendations strengthen Methods was conducted the...
OBJECTIVES: Early studies of venovenous extracorporeal membrane oxygenation (ECMO) in COVID-19 have revealed similar outcomes to historical cohorts. Changes the disease and treatments led differences patients supported on ECMO first second waves. We aimed compare these two groups both acute follow-up phase. DESIGN: Retrospective single-center cohort study comparing mortality at censoring date (November 30, 2021) decannulation, patient characteristics, complications lung function quality life...