A5049892680- Barrier Structure and Function Studies
- Assistive Technology in Communication and Mobility
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Technology Use by Older Adults
- Epilepsy research and treatment
- Chalcogenide Semiconductor Thin Films
- Tracheal and airway disorders
- Quantum Dots Synthesis And Properties
- Drug Transport and Resistance Mechanisms
- Nanocluster Synthesis and Applications
- Language Development and Disorders
- Context-Aware Activity Recognition Systems
- Intracerebral and Subarachnoid Hemorrhage Research
- Adenosine and Purinergic Signaling
Monmouth University
2023-2024
Trinity College Dublin
2006-2024
University College Dublin
2006
Claudin-5 (CLDN5) is an endothelial tight junction protein essential for blood-brain barrier (BBB) formation. Abnormal CLDN5 expression common in brain disease, and knockdown of Cldn5 at the BBB has been proposed to facilitate drug delivery brain. To study consequences loss mature brain, we induced mosaic endothelial-specific gene ablation adult mice (Cldn5iECKO). These displayed increased permeability tracers up 10 kDa size from 6 days post induction (dpi) ensuing lethality dpi. Single-cell...
Individuals with cognitive-communication disorders (CCDs) due to neurological conditions, such as traumatic brain injury and aphasia, experience difficulties in communication cognition that impact their ability perform activities of daily living, or ADLs (e.g., self-care, meal preparation, scheduling). Voice assistive technology (VAT) can support the independent performance ADLs; however, there are limited VAT training programs teach individuals CCDs how properly implement use for ADLs. The...
The first naproxen–QD conjugates have been synthesised and investigated. These demonstrated interesting photophysical properties, good stability in an aggressive enzymatic medium, cellular localisation macrophage (THP-1) cells. nanocomposites might the potential to act as drug delivery imaging agents.
Due to challenges in communication and cognition (e.g., attention, memory, organization, etc.), individuals with cognitive-communication needs (CCNs) experience difficulties performing activities of daily living, or ADLs self-care, meal preparation, managing different routines appointments). Voice-assisted technology (VAT) has been shown support these for ADLs; however, there are limited clinician-guided VAT training programs available CCNs use ADLs. This study aims design implement a 6-week...
Claudin-5 (CLDN5) is an endothelial tight junction protein essential for the integrity of developing blood-brain barrier (BBB). Several brain diseases in humans and mice show abnormal CLDN5 expression, transient downregulation Cldn5 at BBB has been proposed as a strategy drug delivery to brain. To study consequences loss adult brain, we induced knockout mice. This resulted mosaic deletion, causing increased permeability from 7 days post induction lethality 11 induction. Single-cell RNA...