A5044587406- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Biomedical Text Mining and Ontologies
- Dental Implant Techniques and Outcomes
- Genomics and Phylogenetic Studies
- Algorithms and Data Compression
- Medical and Biological Sciences
- Graphene and Nanomaterials Applications
- Spine and Intervertebral Disc Pathology
- Bacteriophages and microbial interactions
- Plant Taxonomy and Phylogenetics
- biodegradable polymer synthesis and properties
- Titanium Alloys Microstructure and Properties
- Orthopedic Infections and Treatments
- 3D Printing in Biomedical Research
- Bacterial biofilms and quorum sensing
- Machine Learning in Bioinformatics
- Genetics, Bioinformatics, and Biomedical Research
- Engineering Technology and Methodologies
- Mesenchymal stem cell research
- Antibiotic Resistance in Bacteria
- Silk-based biomaterials and applications
- Microbial Inactivation Methods
- Bone Metabolism and Diseases
- RNA and protein synthesis mechanisms
Ministry of Health of the Russian Federation
2017-2024
Center for Disease Control
2020-2021
Gamalei Institute of Epidemiology and Microbiology
2014-2018
Lomonosov Moscow State University
2014
Moscow State University
2010
Pseudomonas aeruginosa is one of the most widespread and troublesome opportunistic pathogens that capable colonizing various human tissues organs often resistant to many currently used antibiotics. This resistance caused by different factors, including acquisition specific genes, intrinsic capability diminish antibiotic penetration into bacterial cell, ability form biofilms. situation has prompted development novel compounds differing in their mechanism action from traditional antibiotics...
We report a one-pot plasma electrolytic oxidation (PEO) strategy for forming multi-element oxide layer on the titanium surface using complex electrolytes containing Na2HPO4, Ca(OH)2, (NH2)2CO, Na2SiO3, CuSO4, and KOH compounds. For even better bone implant ingrowth, PEO coatings were additionally loaded with morphogenetic protein-2 (BMP-2). The samples tested in vivo mouse craniotomy model. Tests bactericidal fungicidal activity carried out clinically isolated multi-drug-resistant...
Listeria monocytogenes is a causative agent of foodborne infection in humans and animals. The virulence factor InlB interacts with mammalian receptor c-Met via its internalin domain to provide L. invasion non-professional phagocytes. Naturally occurring variants form four subclusters on the maximal likelihood tree. Four belonging distinct were cloned into vector carrying 3΄ 5΄-flanking sequences restore full length inlB expressed strain EGDeΔinlB. substitutions Val132Ile, Thr117Ala...
Abstract A new dual‐functional implant based on gellan‐xanthan hydrogel with calcium‐magnesium silicate ceramic diopside and recombinant lysostaphin bone morphogenetic protein 2 (BMP‐2)‐ray is developed. In this composite, BMP‐2 immobilized microparticles of while mixed directly into the hydrogel, providing sustained release to allow gradual formation rapid eliminate infection immediately after implantation. Introduction up 3% (w/v) has a negligible effect mechanical properties but provides...
High efficiency of hybrid implants based on calcium-magnesium silicate ceramic, diopside, as a carrier recombinant BMP-2 and xenogenic demineralized bone matrix (DBM) scaffold for tissue regeneration was demonstrated previously using the model critical size cranial defects in mice. In order to investigate possibility these growing autologous vivo bioreactor principle patient's own body, effectiveness ectopic osteogenesis induced by them intramuscular implantation mice studied. At dose 7 μg...
Reconstruction of phylogeny a protein family from sequence alignment can produce results different quality. Our goal is to predict the quality reconstruction basing on features that be extracted input alignment. We used Fitch-Margoliash (FM) method and random forest as predictor. For training testing predictor, alignments orthologous series (OS) were used, for which result evaluated by comparison with trees corresponding organisms. show predicted more than 80% precision. Also, we tried...
Many algorithms and programs are available for phylogenetic reconstruction of families proteins. Methods used widely at present use either a number distance-based principles or character-based maximum parsimony likelihood.We developed novel program, named PQ, reconstructing protein nucleic acid phylogenies following new principle. Being tested on natural sequences PQ improves upon the results likelihood. Working with alignments 10 15 sequences, it also outperforms FastME which is based one...
High efficiency of hybrid implants based on calcium-magnesium silicate ceramic diopside as a carrier recombinant BMP-2 and xenogenic demineralized bone matrix (DBM) scaffold for tissue regeneration was demonstrated previously the model critical size cranial defects in mice. In order to investigate possibility using these growing autologous vivo bioreactor principle patient’s own body, effectiveness ectopic osteogenesis induced by them intramuscular implantation mice studied. At 7 µg dose per...