Sean Darcy

ORCID: 0009-0004-1248-3254
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About
Contact & Profiles
Research Areas
  • Orthopedic Infections and Treatments
  • Orthopaedic implants and arthroplasty
  • Animal Genetics and Reproduction
  • Powder Metallurgy Techniques and Materials
  • Thermoregulation and physiological responses
  • Health Systems, Economic Evaluations, Quality of Life
  • Pelvic and Acetabular Injuries
  • Bone Tissue Engineering Materials
  • Medical Imaging and Analysis
  • Silk-based biomaterials and applications
  • Lipoproteins and Cardiovascular Health
  • Single-cell and spatial transcriptomics
  • Tryptophan and brain disorders
  • Psychedelics and Drug Studies
  • Total Knee Arthroplasty Outcomes
  • Pharmaceutical Economics and Policy
  • Neurotransmitter Receptor Influence on Behavior
  • Vascular Procedures and Complications
  • Intracranial Aneurysms: Treatment and Complications
  • Infrared Thermography in Medicine
  • Surgical Simulation and Training
  • Infectious Aortic and Vascular Conditions

Johns Hopkins University
2021-2025

Johns Hopkins Medicine
2021

University of California, Irvine
2015

University of California, Los Angeles
2009

University at Buffalo, State University of New York
2005

University of Aberdeen
1999-2000

The University of Sydney
1998

In patients with coronary heart disease and a broad range of cholesterol levels, cholesterol-lowering therapy reduces the risk events, but effects on mortality from overall have remained uncertain.In double-blind, randomized trial, we compared pravastatin (40 mg daily) those placebo over mean follow-up period 6.1 years in 9014 who were 31 to 75 age. The had history myocardial infarction or hospitalization for unstable angina initial plasma total levels 155 271 per deciliter. Both groups...

10.1056/nejm199811053391902 article EN New England Journal of Medicine 1998-11-05

Transgenic mice provide unprecedented access to manipulate and visualize neural circuits, however, those on a C57BL/6 background develop progressive hearing loss, significantly confounding systems-level behavioral analysis. While outbreeding can limit it introduces strain variability complicates the generation of complex genotypes. Here, we propose an approach preserve by crossing transgenic with congenic B6.CAST- Cdh23 Ahl+ mice, which maintain low-threshold into adulthood. Widefield...

10.1523/eneuro.0465-24.2025 article EN cc-by-nc-sa eNeuro 2025-02-03

<b>Background</b> The use of nerve conduits to facilitate regrowth after peripheral injury is limited defects less than 3 cm. purpose this study determine the capability novel single and multi-lumen poly(ethylene glycol) (PEG) manufactured by stereolithography promote regeneration. <b>Materials Methods</b> Eight Sprague Dawley rats with sharp transection injuries sciatic were randomly assigned receive single-lumen or PEG bridge a 10-mm gap. Sciatic conduit samples harvested 5 weeks, axon...

10.1055/s-0034-1395415 article EN Journal of Reconstructive Microsurgery 2015-04-20

Transgenic mice provide unprecedented access to manipulate and visualize neural circuits, however, those on a C57BL/6 background develop progressive hearing loss, significantly confounding systems-level behavioral analysis. While outbreeding can limit it introduces strain variability complicates the generation of complex genotypes. Here, we propose an approach preserve by crossing transgenic with congenic B6.CAST- Cdh23 Ahl+ mice, which maintain low-threshold into adulthood. Widefield...

10.1101/2024.10.03.616327 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2024-10-03

Temporal analysis of computerized thermal images can reveal physiological information on skin temperature regulation. Skin oscillates, driven by systemic and local nervous factors. These oscillations, which may be diagnostic value, evaluated in dynamic studies involving the many sequential images. The fundamental regulatory frequencies these oscillations were determined using Fast Fourier Transform average temperatures small areas human back (about 40 mm). Both asymptomatic subjects people...

10.1109/iembs.1990.691905 article EN 2005-08-24
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