A5039224531- Gut microbiota and health
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Probiotics and Fermented Foods
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Microbial Community Ecology and Physiology
- Bacteriophages and microbial interactions
- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Mycobacterium research and diagnosis
Cornell University
2024
New York University
2020-2021
NYU Langone Health
2021
Pulmonary and Critical Care Associates
2020
SleepMed
2020
Rationale: Cross-sectional human data suggest that enrichment of oral anaerobic bacteria in the lung is associated with an increased T-helper cell type 17 (Th17) inflammatory phenotype.Objectives: In this study, we evaluated microbial and host immune-response dynamics after aspiration commensals using a preclinical mouse model.Methods: Aspiration mixture (MOC; Prevotella melaninogenica, Veillonella parvula, Streptococcus mitis) was modeled mice followed by variable time killing. The genetic...
Background Microbiome studies of the lower airways based on bacterial 16S rRNA gene sequencing assess microbial community structure but can only infer functional characteristics. Microbial products, such as short-chain fatty acids (SCFAs), in have significant impact host's immune tone. Thus, approaches to analyses microbiome are necessary. Methods Here we used upper and airway samples from a research bronchoscopy smoker cohort. In addition, validated our results an experimental mouse model....
Inter–microbial and host–microbial interactions are thought to be critical for the functioning of gut microbiome, but few tools available measure these interactions. Here, we report a method unbiased spatial sampling microbiome–host in at one micron resolution. This combines enzymatic situ polyadenylation both bacterial host RNA with RNA–sequencing. Application this mouse model intestinal neoplasia revealed biogeography microbiome as function location intestine, frequent strong...