A5058484738- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Radiopharmaceutical Chemistry and Applications
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Advanced Electron Microscopy Techniques and Applications
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Iron Metabolism and Disorders
- Hematological disorders and diagnostics
- Cell Adhesion Molecules Research
- Hemoglobinopathies and Related Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Stress, Anesthesia, and Immune Response
- Melanoma and MAPK Pathways
- Monoclonal and Polyclonal Antibodies Research
- Information Technology Governance and Strategy
UPMC Hillman Cancer Center
2022-2024
University of Pittsburgh Medical Center
2022-2024
University of Pittsburgh
2014-2024
Canberra (United Kingdom)
2020
University of Nottingham
1997
The lack of techniques for noninvasive imaging inflammation has challenged precision medicine management acute respiratory distress syndrome (ARDS). Here, we determined the potential positron emission tomography (PET) chemokine-like receptor-1 (CMKLR1) to monitor lung in a murine model lipopolysaccharide-induced injury. Lung uptake CMKLR1-targeting radiotracer, [ 64 Cu]NODAGA-CG34, was significantly increased injury, correlated with expression multiple inflammatory markers, and reduced by...
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Immunotherapy may be promising for treatment of some patients with GBM; however, there a need noninvasive neuroimaging techniques to predict immunotherapeutic responses. The effectiveness strategies requires T-cell activation. Therefore, we aimed evaluate an early marker activation, CD69, its use as imaging biomarker response immunotherapy GBM. Herein, performed CD69 immunostaining on human mouse T cells...
Precision management of fibrotic lung diseases is challenging due to their diverse clinical trajectories and lack reliable biomarkers for risk stratification therapeutic monitoring. Here, we validated the accuracy CMKLR1 as an imaging biomarker inflammation-fibrosis axis. By analyzing single-cell RNA sequencing datasets, demonstrated
Abstract In sickle cell disease (SCD), very late antigen-4 (VLA-4 or integrin α4β1) mediates the adhesion of reticulocytes to inflamed, proinflammatory endothelium, a key process in promoting vaso-occlusive episodes (VOEs). We hypothesized that radionuclide tracer targeting VLA-4 could be harnessed as positron emission tomography (PET) imaging biomarker VOEs. tested peptidomimetic PET 64Cu-CB-TE1A1P-PEG4-LLP2A (64Cu-LLP2A) for hyper-adhesion–associated VOEs SCD Townes mouse model. With...
Inflammation plays a central role in the pathogenesis of acute lung injury (ALI) during both pneumonitis stage and progression into chronic fibroproliferative phase, leading to pulmonary fibrosis. Currently, there is an unmet clinical research need for noninvasive ways monitor inflammation through targeting immunoregulatory pathways contributing ALI pathogenesis. In this study, we evaluated targeted imaging very late antigen-4 (VLA-4), as key integrin mediating adhesion recruitment immune...
Abstract Background The liver is a common site for metastatic disease variety of cancers, including colorectal cancer. Both primary and secondary tumors are supplied through the hepatic artery while healthy by portal vein. Transarterial radioembolization (TARE) using yttrium-90 glass or resin microspheres have shown promising results with reduced side-effects but similar survival benefits as chemoembolization in patients hepatocellular carcinoma (HCC). This highlights need new novel agents...
Glioblastoma (GBM) is the most common primary malignant brain tumor. Currently, there are few effective treatment options for GBM beyond surgery and chemo-radiation, even with these interventions, median patient survival remains poor. While immune checkpoint inhibitors (ICIs) have demonstrated therapeutic efficacy against non-central nervous system cancers, ICI trials typically had poor outcomes. TIGIT an receptor that expressed on activated T-cells has a role in suppression of T-cell...
Surgical resection is integral for the treatment of neuroblastoma, most common extracranial solid malignancy in children. Safely locating and resecting primary tumor remote deposits disease remains a significant challenge, resulting high rates complications incomplete surgery, worsening outcomes. Intraoperative molecular imaging (IMI) uses targeted radioactive or fluorescent tracers to identify visualize tumors intraoperatively. GD2 was selected as an IMI target, it highly overexpressed...
We propose a combined physical/data link layer protocol for satellite communications that contains markers which allow real-time Doppler synchronization on the satellite. Traditionally, communication protocols many cube- and nano satellites utilize data such as AX.25 or CC11XX, also are widely used in ground based networks. Ground protocols, CC11XX sequence at beginning of packet demodulator to achieve carrier symbol synchronization. This is sufficient stationary slow moving transceivers....
Abstract Background The lack of noninvasive methods for assessment dysregulated inflammation as a major driver fibrosis (i.e., inflammation-fibrosis axis) has been challenge to precision management fibrotic lung diseases. Here, we determined the potential very late antigen-4 (VLA-4)-targeted positron emission tomography (PET) detect in mouse model bleomycin-induced injury. Method Single time-point and longitudinal VLA-4-targeted PET was performed using high-affinity peptidomimetic...
Abstract Lung cancer is the second most common in both men and women US leading cause of death. Among younger women, lung incidence rates have recent years become higher than seen men, despite comparable histories tobacco use. The possible contribution stress to risk young has received little research attention preclinical evidence that exposure stress-related neuroendocrine responses can DNA damage. present study used a well-established model female mice (in vivo NNK) along with mouse...
<h3>Objective:</h3> We aimed to evaluate an early marker of T-cell activation, CD69, for its use as imaging biomarker response immunotherapy GBM. <h3>Background:</h3> Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Immunotherapy may be promising treatment some GBM patients, however, there a need non invasive neuroimaging techniques predict immunotherapeutic responses. The effectiveness strategies requires T-cells activation. <h3>Design/Methods:</h3>...
<div>Abstract<p>Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Immunotherapy may be promising for treatment of some GBM patients, however, there a need non-invasive neuroimaging techniques to predict immunotherapeutic responses. The effectiveness strategies requires T-cells activation. Therefore, we aimed evaluate an early marker T-cell activation, CD69, its use as imaging biomarker response immunotherapy GBM. Herein, performed CD69...
<p>CD69 is upregulated upon T-cell activation.</p>
<div><p>Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Immunotherapy may be promising for treatment of some patients with GBM; however, there a need noninvasive neuroimaging techniques to predict immunotherapeutic responses. The effectiveness strategies requires T-cell activation. Therefore, we aimed evaluate an early marker activation, CD69, its use as imaging biomarker response immunotherapy GBM. Herein, performed CD69 immunostaining on human...
<p>CD69 is upregulated upon T-cell activation.</p>
<p>MRI analysis of tumor volume prior to immuno-PET.</p>
<p>MRI analysis of tumor volume before and after treatment.</p>