Nicholas Olden

ORCID: 0009-0004-2454-0885
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About
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Research Areas
  • Pancreatic and Hepatic Oncology Research
  • Cancer Genomics and Diagnostics
  • MicroRNA in disease regulation
  • Epigenetics and DNA Methylation
  • Pancreatitis Pathology and Treatment
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Single-cell and spatial transcriptomics
  • Fire Detection and Safety Systems
  • Oil Spill Detection and Mitigation
  • Risk and Safety Analysis

Gift of Life Michigan
2023

Abstract The adult healthy human pancreas has been poorly studied given the lack of indication to obtain tissue from in absence disease and rapid postmortem degradation. We obtained pancreata brain dead donors, thus avoiding any warm ischemia time. 30 donors were diverse age race had no known disease. Histopathologic analysis samples revealed pancreatic intraepithelial neoplasia (PanIN) lesions most individuals irrespective age. Using a combination multiplex IHC, single-cell RNA sequencing,...

10.1158/2159-8290.cd-23-0013 article EN cc-by-nc-nd Cancer Discovery 2023-04-06

Abstract The adult healthy human pancreas has been poorly studied given lack of indication to obtain tissue from the in absence disease and rapid postmortem degradation. We obtained pancreata brain dead donors thus avoiding any warm ischemia time. 30 were diverse age race had no known disease. Histopathological analysis samples revealed PanIN lesions most individuals irrespective age. Using a combination multiplex immunohistochemistry, single cell RNA sequencing, spatial transcriptomics, we...

10.1101/2023.01.13.523300 preprint EN cc-by-nd bioRxiv (Cold Spring Harbor Laboratory) 2023-01-15

<div>Abstract<p>The adult healthy human pancreas has been poorly studied given lack of indication to obtain tissue from the in absence disease and rapid postmortem degradation. We obtained pancreata brain dead donors thus avoiding any warm ischemia time. The 30 were diverse age race had no known disease. Histopathological analysis samples revealed PanIN lesions most individuals irrespective age. Using a combination multiplex immunohistochemistry, single cell RNA sequencing,...

10.1158/2159-8290.c.6651113.v4 preprint EN 2024-09-16

<div>Abstract<p>The adult healthy human pancreas has been poorly studied given lack of indication to obtain tissue from the in absence disease and rapid postmortem degradation. We obtained pancreata brain dead donors thus avoiding any warm ischemia time. The 30 were diverse age race had no known disease. Histopathological analysis samples revealed PanIN lesions most individuals irrespective age. Using a combination multiplex immunohistochemistry, single cell RNA sequencing,...

10.1158/2159-8290.c.6651113.v3 preprint EN 2024-09-16

Public perception and environmental awareness place increasing demands on the petroleum industry to facilitate fast efficient oil spill containment recovery mitigate damage. HSE legislation also places Oil Spill Response Organisations ensure a safe working environment for responders. This paper looks at trade-offs facing response planning from perspective of occupational exposure Total Volatile Hydrocarbons (TVH). TVH is term used represent large group consisting hundreds chemical compounds...

10.7901/2169-3358-2005-1-979 article EN International Oil Spill Conference Proceedings 2005-05-01

<div>Abstract<p>The adult healthy human pancreas has been poorly studied given lack of indication to obtain tissue from the in absence disease and rapid postmortem degradation. We obtained pancreata brain dead donors thus avoiding any warm ischemia time. The 30 were diverse age race had no known disease. Histopathological analysis samples revealed PanIN lesions most individuals irrespective age. Using a combination multiplex immunohistochemistry, single cell RNA sequencing,...

10.1158/2159-8290.c.6651113 preprint EN 2023-05-17

<div>Abstract<p>The adult healthy human pancreas has been poorly studied given the lack of indication to obtain tissue from in absence disease and rapid postmortem degradation. We obtained pancreata brain dead donors, thus avoiding any warm ischemia time. The 30 donors were diverse age race had no known disease. Histopathologic analysis samples revealed pancreatic intraepithelial neoplasia (PanIN) lesions most individuals irrespective age. Using a combination multiplex IHC,...

10.1158/2159-8290.c.6651113.v1 preprint EN 2023-05-17
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