A5094027460- Cardiac Valve Diseases and Treatments
- Diet, Metabolism, and Disease
- Dental Implant Techniques and Outcomes
- Cardiovascular Disease and Adiposity
- Protease and Inhibitor Mechanisms
- Platelet Disorders and Treatments
- Liver Disease Diagnosis and Treatment
Harvard University
2024
Brigham and Women's Hospital
2024
In calcific aortic valve disease (CAVD), mechanosensitive valvular cells respond to fibrosis- and calcification-induced tissue stiffening, further driving pathophysiology. No pharmacotherapeutics are available treat CAVD because of the paucity (i) appropriate experimental models that recapitulate this complex environment (ii) benchmarking novel engineered (AV)–model performance. We established a biomaterial-based model mimicking biomechanics human AV disease-prone fibrosa layer,...
Background: Inflammation and lipid accumulation are major features of atherosclerosis, a leading cause death morbidity worldwide. Our previous study recognized ADP-ribosylation, post-translational modification, as novel regulator macrophage activation. We also have established mass spectrometry-based ADP-ribosylation proteomics. Using this technology, we evaluated the completely uncharacterized role in atherogenesis. hypothesized that ADP-ribosylated proteins circulate from liver, accumulate...
Introduction: Fibrocalcific remodeling is an end-stage feature of bioprosthetic (BP) structural valve degeneration and calcific aortic (AV) disease. However, the processes governing BP calcification are understudied. Here we conduct a histopathological assessment in position build proteomic comparison map versus AV disease humans. Methods: Macroscopic segmentation was performed on entire explanted degenerated bovine pericardial leaflets (n=48) diseased valves (n=19) validated with histology...