About
Contact & Profiles
A5093860896
Research Areas
- Genetic Neurodegenerative Diseases
- Fungal and yeast genetics research
- Endoplasmic Reticulum Stress and Disease
Children's Hospital of Philadelphia
2024
University of Pennsylvania
2024
The presence of large protein inclusions is a hallmark neurodegeneration, and yet the precise molecular factors that contribute to their formation remain poorly understood. Screens using aggregation-prone proteins have commonly relied on downstream toxicity as readout rather than direct aggregates. Here, we combined genome-wide CRISPR knockout screen with Pulse Shape Analysis, FACS-based method for inclusion detection, identify modifiers TDP-43 aggregation in human cells. Our revealed both...
10.1371/journal.pgen.1011138
article
EN
cc-by
PLoS Genetics
2024-02-05
Coming Soon ...