A5014927425- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer-related gene regulation
- Antimicrobial Peptides and Activities
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- PARP inhibition in cancer therapy
- Immune Cell Function and Interaction
- Ovarian cancer diagnosis and treatment
- Cancer, Hypoxia, and Metabolism
Kettering University
2023-2024
Memorial Sloan Kettering Cancer Center
2022-2024
Stony Brook School
2024
Stony Brook University
2024
Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic stem progenitor compartments in blood. Hematopoietic cells (HSCs) are essential for long-term repopulation secondary transplantation. Here, using a conditional knockout mouse model, we revealed that RNA-binding protein SYNCRIP required maintenance of blood especially regenerative due to defects HSCs progenitors. Mechanistically, find loss results failure maintain proteome HSC maintenance. depletion...