A5027861517- Protein Tyrosine Phosphatases
- ATP Synthase and ATPases Research
- Bioactive Compounds and Antitumor Agents
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Columbia University
2023
Protein tyrosine phosphatases (PTPs) are an important class of enzymes that modulate essential cellular processes through protein dephosphorylation and dysregulated in various disease states. There is demand for new compounds target the active sites these enzymes, use as chemical tools to dissect their biological roles or leads development therapeutics. In this study, we explore array electrophiles fragment scaffolds investigate required parameters covalent inhibition phosphatases. Our...
Protein tyrosine phosphatases (PTPs) are an important class of enzymes that modulate essential cellular processes through protein dephosphorylation and dysregulated in various disease states. There is demand for new compounds target the active sites these enzymes, use as chemical tools to dissect their biological roles or leads development therapeutics. In this study, we explore array electrophiles fragment scaffolds investigate required parameters covalent inhibition phosphatases. Our...