A5036324557- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Pancreatitis Pathology and Treatment
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Cytomegalovirus and herpesvirus research
- Tracheal and airway disorders
- Herpesvirus Infections and Treatments
- Ear Surgery and Otitis Media
- Micro and Nano Robotics
- Amoebic Infections and Treatments
- Photosynthetic Processes and Mechanisms
- DNA Repair Mechanisms
- Viral-associated cancers and disorders
- Plant Reproductive Biology
- Infections and bacterial resistance
- Antibiotic Resistance in Bacteria
- Respiratory and Cough-Related Research
Medical College of Wisconsin
2022-2024
Achromobacter xylosoxidans (Ax) is an opportunistic pathogen and causative agent of numerous infections particularly in immunocompromised individuals with increasing prevalence cystic fibrosis (CF). To date, investigations have focused on the clinical epidemiology genomic comparisons Ax isolates, yet little known about disease pathology or role that specific virulence factors play tissue invasion damage. Here, we model acute lung infection immunocompetent C57BL/6 mice CF mice, revealing a...
Adherence of nontypeable Haemophilus influenzae (NTHi) to the host airway is an essential initial step for asymptomatic colonization nasopharynx, as well development disease. NTHi relies on strict regulation multiple adhesins adherence substrates encountered in airway. encode a phase-variable cytoplasmic DNA methyltransferase, ModA, that regulates expression genes; phasevarion (phase-variable regulon). Multiple modA alleles are present NTHi, which different methylate target, and each...
Non-typeable Haemophilus influenzae (NTHi) causes millions of infections each year. Though it is primarily known to cause otitis media, recent studies have shown NTHi emerging as a primary pathogen for invasive infection, prompting the need new vaccines and treatments. Lipooligosaccharide (LOS) has been identified potential vaccine candidate due its immunogenic nature outer membrane localization. Yet, phase variable expression genes involved in LOS synthesis complicated development. In this...
Abstract Adherence of non-typeable Haemophilus influenzae (NTHi) to the host airway is an essential initial step for asymptomatic colonization nasopharynx, as well development disease. NTHi relies on strict regulation multiple adhesins its pathogenesis. The ModA phasevarion a bacterial regulatory system important virulence NTHi. However, role in adherence not understood well. This study addressed substrates airway. Assessment modA variants four clinical isolates showed that phasevarions...