A5023760677- Cancer-related Molecular Pathways
- Melanoma and MAPK Pathways
- Computational Drug Discovery Methods
- Platelet Disorders and Treatments
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Advanced Proteomics Techniques and Applications
- Mast cells and histamine
- Protein Kinase Regulation and GTPase Signaling
- Bioinformatics and Genomic Networks
- Data Management and Algorithms
- FOXO transcription factor regulation
- Acute Myeloid Leukemia Research
- Microtubule and mitosis dynamics
- Plant Molecular Biology Research
- Multiple Myeloma Research and Treatments
- Mass Spectrometry Techniques and Applications
- Ion channel regulation and function
- Microbial Natural Products and Biosynthesis
- Blood Coagulation and Thrombosis Mechanisms
- 14-3-3 protein interactions
- Heat shock proteins research
- Ion Channels and Receptors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
FHNW University of Applied Sciences and Arts
2023
ETH Zurich
2013-2020
Friedrich Miescher Institute
2006-2010
University of Bern
2004-2006
Abstract Mass spectrometry is the method of choice for deep and reliable exploration (human) proteome. Targeted mass reliably detects quantifies pre-determined sets proteins in a complex biological matrix used studies that rely on quantitatively accurate reproducible measurement across multiple samples. It requires one-time, priori generation specific assay each targeted protein. SWATH-MS spectrometric combines data-independent acquisition (DIA) data analysis vastly extends throughput can be...
Highlights•A high-confidence interaction proteome for the human CMGC kinase family•Organization of kinases in kinase-kinase subnetworks•Network inference revealed kinase-substrates modules•Discovery 108 physical interactions between and disease-associated proteinsSummaryCellular information processing via reversible protein phosphorylation requires tight control localization, activity, substrate specificity kinases, which to a large extent is accomplished by complex formation with other...
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, cell cycle. Despite the critical role in cells their strong association with diseases, good coverage interactions is available only a fraction 535 human kinases. Here, we present comprehensive mass-spectrometry-based analysis kinase interaction network covering more than 300 The dataset high-quality resource 5,000 previously unreported...
Abstract Despite the great success of small molecule inhibitors in treatment patients with BRAF V600E mutated melanoma, response to these drugs remains transient and eventually relapse within a few months, highlighting need develop novel combination therapies based on understanding molecular changes induced by inhibitors. The acute inhibition oncogenic signaling can rewire entire cellular pathways thereby create cancer cell vulnerabilities. Here, we demonstrate that melanoma lines leads...