A5032304818- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Veterinary Medicine and Surgery
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical Analysis and Sensing Techniques
- Silk-based biomaterials and applications
- Peroxisome Proliferator-Activated Receptors
- Genomics and Phylogenetic Studies
- Enzyme Production and Characterization
- Human-Animal Interaction Studies
- Tendon Structure and Treatment
- Total Knee Arthroplasty Outcomes
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Milk Quality and Mastitis in Dairy Cows
- RNA Research and Splicing
- Infant Nutrition and Health
- melanin and skin pigmentation
- RNA modifications and cancer
- Genetic and phenotypic traits in livestock
- Probiotics and Fermented Foods
- Marine Biology and Environmental Chemistry
Adam Mickiewicz University in Poznań
2023-2025
University of Life Sciences in Poznań
2011-2019
Polish Academy of Sciences
2015
Freie Universität Berlin
2008
The functional outcomes of arthroscopic matrix-based meniscus repair (AMMR) in patients two and five years after the treatment clearly show that use collagen matrix bone marrow aspirate creates favorable biological conditions for healing. This study not only provides ten follow-up results but also investigates biomolecular mechanisms governing regenerative process.Case series was based on data collected from who underwent AMMR procedure, starting with preoperatively through two-year...
This study aims to present an easily scalable, cost-efficient process of dECM extraction from porcine meniscus, dedicated bioink preparation and 3D bioprinting. Due its cartilage like structure mechanical robustness, the meniscus is exceptionally demanding tissue for decellularisation ECM. Its processing poses a great difficulty renders methods previously developed soft tissues useless. A process, combining homogenisation, hydrolysis, supercritical CO2 (scCO2) lyophilisation, was meet this...
Summary Obesity is an emerging health problem in purebred dogs. Due to their crucial role energy homeostasis control, genes encoding adipokines are considered candidate genes, and variants may be associated with predisposition obesity. Searching for polymorphism was carried out three adipokine ( TNF , RETN IL 6) . The study performed on 260 dogs, including lean n = 109), overweight 88) obese 63) largest cohort represented by Labrador Retrievers 136). Altogether, 24 novel polymorphisms were...
Summary Pork quality depends on multiple factors, including fatty acid composition in muscle and fat tissues. The ME 1 gene is a strong candidate for accumulation, as it encodes the malic enzyme, which required synthesis. We identified seven new polymorphisms 3′ UTR of moreover confirmed presence 4 detected previously. Interestingly, studied Duroc pigs were monomorphic at all these polymorphic sites, while 3 other breeds (Pietrain, Polish Landrace Large White), unevenly distributed. One...
Abstract The leptin gene (LEP) is considered as a functional candidate for production traits in livestock due to its crucial role energy homeostasis. Because polymorphisms regulatory sequences may affect expression, we searched them the 3′UTR of LEP and analyzed their association with traits. Four breeds composite line were studied. In Polish Landrace Large White breeds, 8 SNPs 1 indel observed; whereas, Duroc breed, 9 specific found. Pietrain Line 990 monomorphic. One SNP (g.+168C>T),...
The dog is considered to be a useful biomedical model for human diseases and disorders, including obesity. One of the numerous genes associated with polygenic obesity MC4R, encoding melanocortin 4 receptor. aim our study was analyze polymorphisms methylation canine MC4R in relation adiposity. Altogether 270 dogs representing four breeds predisposed obesity: Labrador Retriever (n = 187), Golden 38), Beagle 28) Cocker Spaniel 17), were studied. classified into three groups: lean, overweight...
Abstract Obesity is a serious problem in numerous dog breeds, but knowledge of its hereditary background scarce. On the contrary, DNA polymorphisms associated with human obesity have been identified, strongest effect being demonstrated for FTO gene. We used targeted next-generation sequencing (tNGS) to search region harboring and IRX3 32 Labrador dogs. Moreover, we investigated selected regions , orthologous obesity, 165 Labradors. For all dogs, following information was available: age, sex,...
Figure S1 Missense SNPs found in CSN2 and CSN3 genes. Table PCR conditions for porcine gene amplification. As a service to our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer-reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should addressed Please note: The publisher is responsible content functionality of any Any queries content)...