Shane Farrell
A5105723368- Metabolomics and Mass Spectrometry Studies
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Analytical Chemistry and Chromatography
- Advanced Chemical Sensor Technologies
- Marine and coastal ecosystems
- Microbial Community Ecology and Physiology
Bigelow Laboratory for Ocean Sciences
2023-2025
University of Maine
2023-2025
University of Tübingen
2024
Dissolved organic matter (DOM) is an ultracomplex mixture that plays a central role in global biogeochemical cycles. Despite its importance, DOM remains poorly understood at the molecular level. Over last decades, significant efforts have been made to decipher chemical composition of by high-resolution mass spectrometry (HR-MS) and liquid chromatography (LC) coupled with tandem (MS/MS). Yet, complexity high degree nonresolved isomers still hamper full structural analysis DOM. To address this...
Feature-Based Molecular Networking (FBMN) is a popular analysis approach for LC-MS/MS-based non-targeted metabolomics data. While processing LC-MS/MS data through FBMN fairly streamlined, downstream handling and statistical interrogation often key bottleneck. Especially, users new to struggle effectively handle analyze complex matrices. In this protocol, we provide comprehensive guide the of results. We explain structure principles clean-up normalization, as well uni- multivariate...
In temperate regions experiencing rapid ocean warming, kelp forests are being replaced by chemically rich turf algae. However, the extent to which these algae alter surrounding chemical environment or affect rebound potential of (through mediated interactions) remains unknown. Here, we used underwater visual surveys, comprehensive profiling, and laboratory experiments reveal that release bioactive compounds into water fundamentally reef “chemical landscape” directly suppress recruitment....
Dissolved organic matter (DOM) is one of the most complex chemical mixtures and plays a central role in biogeochemical cycles across our ecosphere. Despite its importance, DOM remains poorly understood at molecular level. Over last decades, significant efforts have been made to decipher composition by high-resolution mass spectrometry (HRMS) liquid chromatography (LC) coupled with tandem (MS/MS). Yet, complexity high degree non-resolved isomers still hamper full structural analysis DOM. To...