A5102866472- Cell death mechanisms and regulation
- Spectroscopy and Chemometric Analyses
- Mitochondrial Function and Pathology
- Calpain Protease Function and Regulation
- Genomics and Phylogenetic Studies
- Cardiac Ischemia and Reperfusion
- Identification and Quantification in Food
- Autophagy in Disease and Therapy
- Topic Modeling
- Microstructure and Mechanical Properties of Steels
- High Altitude and Hypoxia
- Advanced Chemical Sensor Technologies
- Microwave Engineering and Waveguides
- Birth, Development, and Health
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- Cannabis and Cannabinoid Research
- Metabolomics and Mass Spectrometry Studies
- Natural Language Processing Techniques
- Wheat and Barley Genetics and Pathology
- Coagulation and Flocculation Studies
- Bioactive natural compounds
- Image and Signal Denoising Methods
- Spondyloarthritis Studies and Treatments
- Immune Cell Function and Interaction
Nanjing University of Aeronautics and Astronautics
2024-2025
Jimei University
2023-2024
Fujian Fisheries Research Institute
2024
Wuhan University of Science and Technology
2023-2024
Beijing University of Posts and Telecommunications
2023
Weatherford College
2023
Xiamen University of Technology
2023
Xiamen Medical College
2023
Nextomics Biosciences (China)
2018-2023
Grandomics (China)
2020-2023
Summary The fraudulent practice of beef adulteration is a growing concern, as it violates consumer rights. Electrical impedance spectroscopy (EIS) combined with machine learning has emerged widely used approach to identify low‐quality meat. Unlike traditional biochemical methods that require expensive instruments, complex sample preparation, and chemical reagents, EIS cost‐effective alternative. However, data are susceptible temperature fluctuations, requiring waiting period under consistent...
Chronic hypoxia during pregnancy is one of the most common insults to fetal development. We tested hypothesis that maternal induced apoptosis in hearts near-term rats. Pregnant rats were divided into two groups, normoxic control and continuous hypoxic exposure (10.5% O 2 ) from day 15 21 gestation. Hearts isolated 21-day gestational age. Maternal increased hypoxia-inducible factor-1α protein hearts. significantly percentage size binucleated myocytes apoptotic cells 1.4 ± 0.14% 2.7 0.3%...
In the present study, we examined direct cytotoxic effects of cocaine on fetal cardiac myocytes. Cocaine treatment cultured rat (21 days) myocardial cells (FRMCs) induced a time- and concentration-dependent increase in apoptotic FRMCs. surface exposure phosphatidylserine FRMCs at 12-h increased up to 96 h. Corresponding DNA fragmentation by these was demonstrated situ terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling assay electrophoresis labeled fragments, showing...
Abstract The circadian clock enables organisms to rapidly adapt the ever‐changing environmental conditions that are caused by daily light/dark cycles. Circadian genes universally affect key agricultural traits, particularly flowering time. Here, we show OsPRR37 , a gene, delays rice time in an expression level‐dependent manner. Using high‐throughput mRNA sequencing on overexpressing transgenic line ( ‐OE5) and recipient parent Guangluai4 contains loss‐of‐function Osprr37 identify 14,992...
Divergent selection of populations in contrasting environments leads to functional genomic divergence. However, the architecture underlying heterogeneous differentiation remains poorly understood. Here, we de novo assembled two high-quality wild barley (Hordeum spontaneum K. Koch) genomes and examined gene expression patterns under abiotic stress populations. These had a shared ancestry originated close geographic proximity but experienced different selective pressures due their...
Few-shot named entity recognition (NER) involves identifying specific entities using limited data. Metric learning-based methods, which compute token-level similarities between query and support sets to identify target entities, have demonstrated remarkable performance in this task. However, their effectiveness deteriorates when the distribution of set differs from that set. To address issue, we propose a novel approach leverages synergy large language model (LLM) metric few-shot NER...
Structural variants (SVs), accounting for a larger fraction of the genome than SNPs/InDels, are an important pool genetic variation, enabling environmental adaptations. Here, we perform long-read sequencing data 320 Tibetan and Han samples show that SVs highly involved in high-altitude adaptation. We expand landscape global SVs, apply robust models selection population differentiation combining SNPs InDels, use epigenomic analyses to predict enhancers, target genes biological functions....
This study delved into the impact of aging on properties five common microplastic types, including polymethylmethacrylate (PMMA), polystyrene (PS), polyvinyl chloride (PVC), polyethylene (PE), and polypropylene (PP). The process significantly altered particle size distribution: PS, PP, PMMA underwent a contraction, with average sizes decreasing by 6.8%, 3.2%, 1.7%, respectively, whereas PE PVC experienced an expansion, increases 3.1% 1.7%. Notably, generally increased specific surface area...
Summary Unscrupulous merchants would sell cheap, low‐nutrition formula milk powder as pasteurised milk, or use it a raw material in dairy products, for the purpose of making profit. Currently, biochemical methods are utilised to identify type processed which could involve chemical reagents, sample preparation and costly instruments. This paper investigates utility electrical impedance spectroscopy (EIS) distinguishing different types milk. Ultra‐high temperature sterilised were studied. The...
Cocaine induces apoptosis in coronary artery endothelial cells. Yet the cellular and molecular mechanisms are not clear. Given that cocaine has profound toxic effects on mitochondria, present study examined role of mitochondrial cytochrome c cocaine-mediated apoptosis. Using cultured bovine cells, we found cocaine-induced was dose dependently inhibited by cyclosporin A with IC(50) 0.2 microM. The maximum 65% inhibition obtained 3 microM A. induced a translocation from mitochondria to cytosol...
Cocaine induces apoptosis in fetal rat myocardial cells (FRMCs). However, the mechanisms are not clear. The present study examined role of p38 mitogen-activated protein kinase (MAPK) and cytochrome <i>c</i> release cocaine-induced primary culture FRMCs prepared from heart gestational age 21 days. induced time-dependent, concurrent increases activities caspase-9 caspase-3, which preceded apoptosis. Caspase-8 was activated. In accordance, cyclosporin A inhibitors caspase-3 inhibited caspase...
Abstract Wild barley, from “Evolution Canyon (EC)” in Mount Carmel, Israel, are ideal models for cereal chromosome evolution studies. Here, the wild barley EC_S1 is south slope with higher daily temperatures and drought, while EC_N1 north a cooler climate relative humidity, which results differentiated selection due to contrasting environments. We assembled 5.03 Gb genome contig N50 of 3.53 Mb 5.05 3.45 using 145 160.0 Illumina sequencing data, 295.6 285.35 Nanopore data 555.1 514.5 Hi-C...
We have previously demonstrated that cocaine induces apoptosis in primary cultures of fetal rat cardiomyocytes. The current study was designed to determine whether administered the mother during pregnancy induced heart. Pregnant rats were treated with subcutaneously (30 and 60 mg/kg per day) starting at day 15 gestation terminated 21. Cocaine produced a dose-dependent increase apoptotic cell death heart by 1.3-fold 2.4-fold (60 control level (1.99 ± 0.15%). Cocaine-induced DNA fragmentation...
Genome-wide association studies (GWAS) have been widely used for identifying potential risk variants in various diseases. A statistically meaningful GWAS typically requires a large sample size to detect disease-associated single nucleotide polymorphisms (SNPs). However, institution usually only possesses limited number of samples. Therefore, cross-institutional partnerships are required increase and statistical power. offer significant challenges, major one being data privacy. For example,...
The present study examined the role of nitric oxide in cocaine-induced apoptosis bovine coronary artery endothelial cells (BCAECs). Cocaine produced a time-dependent decrease cell viability and an increase BCAECs, which were blocked by donors DETA-NONOate (DETA-NO) S-nitroso-N-acetyl-penicillamine. In accordance, cocaine decreased production BCAECs at each time point study. significantly increased caspase-3 activity that was inhibitors cytochrome c release (cyclosporin A), (Ac-DEVD-CHO),...
This study was designed to determine the direct cytotoxic effect of cocaine on human coronary artery endothelial cells (HCAECs). Cocaine treatment cultured HCAECs induced a time- and dose-dependent increase in apoptotic cell death HCAECs. Cocaine-induced surface exposure phosphatidylserine seen as early at 6 h. With prolonged < or =72 h, (10-500 microM) produced apoptosis cells. Corresponding DNA fragmentation by demonstrated situ terminal deoxynucleotidyl transferase (Tdt) UTP nick...
The importance of structural variants (SVs) for human phenotypes and diseases is now recognized. Although a variety SV detection platforms strategies that vary in sensitivity specificity have been developed, few benchmarking procedures are available to confidently assess their performances biological clinical research. To facilitate the validation application these approaches, we established an Asian reference material by characterizing genome Epstein-Barr virus (EBV)-immortalized B...
The pH and dissolved oxygen (DO) conditions are important environmental factors that control the migration of arsenic (As) at sediment-water interface. This study investigates distribution differences reactive iron, manganese, interface under anaerobic aerobic different levels. strong buffering capacity sediment to water results in a shift towards neutral values overlying initial conditions. level DO becomes key factor release As from sediment, with lower environments exhibiting higher...
Ger mination of sesame seeds in acidic and indole-3-acetic acid (IAA) liquid mediums was investigated using single pulse 1H spectroscopy chemical shift selection imaging. The spectra images demonstrated high correlation reliability. Chemical imaging allowed for an intuitive comprehension the dynamic distribution metabolites structural changes during germination, leading to a clearer understanding IAA’s regulation on metabolites, when combined with spectra. Results showed that exogenous...