A5101581440- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Clostridium difficile and Clostridium perfringens research
- Advanced biosensing and bioanalysis techniques
- Shoulder Injury and Treatment
- Venous Thromboembolism Diagnosis and Management
- Systemic Sclerosis and Related Diseases
- RNA and protein synthesis mechanisms
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Fibrosis and Remodeling
- Cardiomyopathy and Myosin Studies
- Microfluidic and Bio-sensing Technologies
- Surgical Simulation and Training
- Peripheral Artery Disease Management
- RNA Research and Splicing
Boston University
2024
University of Tennessee at Chattanooga
2012
University of Calgary
2010
Heterozygous truncating variants in the sarcomere protein titin (TTN) are most common genetic cause of heart failure. To understand mechanisms that regulate abundant cardiomyocyte TTN expression we characterized highly conserved intron 1 sequences exhibited dynamic changes chromatin accessibility during differentiation human cardiomyocytes from induced pluripotent stem cells (hiPSC-CMs). Homozygous deletion these mice caused embryonic lethality while heterozygous demonstrated allele-specific...
Hypertrophic cardiomyopathy (HCM) is characterized by thickening of the left ventricular wall, diastolic dysfunction, and fibrosis, associated with mutations in genes encoding sarcomere proteins. While vitro studies have used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to study HCM, these models not examined multicellular interactions involved fibrosis. Using engineered cardiac microtissues (CMTs) composed HCM-causing MYH7 -variant hiPSC-CMs wild-type fibroblasts,...
Abstract Understanding the structural and functional development of human-induced pluripotent stem-cell-derived cardiomyocytes (hiPSC-CMs) is essential to engineering cardiac tissue that enables pharmaceutical testing, modeling diseases, designing therapies. Here we use a method not commonly applied biological materials, small angle x-ray scattering, characterize hiPSC-CMs within three-dimensional engineered tissues during their preliminary stages maturation. An scattering experimental...
Abstract Understanding the structural and functional development of human-induced pluripotent stem-cell-derived cardiomyocytes is essential to engineering cardiac tissue that enables pharmaceutical testing, modeling diseases, designing therapies. Here, we used a method not commonly applied biological materials, small angle X-ray scattering characterize human induced within 3D engineered tissues during their preliminary stages maturation. An innovative experimental setup enabled visualization...