A5089031398- DNA Repair Mechanisms
- Liver Disease Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Medical Research and Treatments
- Traditional Chinese Medicine Studies
- Epigenetics and DNA Methylation
Sichuan University
2022-2023
State Key Laboratory of Biotherapy
2022
H2BK120ub1 triggers several prominent downstream histone modification pathways and changes in chromatin structure, therefore involving it into multiple critical cellular processes including DNA transcription damage repair. Although has been reported that is mediated by RNF20/40 CRL4 WDR70 , less known about the underlying regulation mechanism for WDR70. By using a series of biochemical cell-based studies, we find promotes interacting with complex, deposition H3K79me2 POLE3 loci highly...
Weiyan mixture (WYM) is effectively used for the treatment of gastrointestinal diseases, while mechanism WYM in chronic atrophic gastritis (CAG) has not been systematically investigated. The aim this study was to explore therapeutic effects and potential CAG through UPLC/MS-based metabolomics combined with network pharmacology. Firstly, gastric tissue damage rats concentrations IL-6, IL-1β, TNF-α IL-10 rat serum were detected by immunohistochemical staining ELISA analysis, respectively....