A5053557363- RNA Research and Splicing
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- HIV Research and Treatment
National Center of Biomedical Analysis
2023-2025
Jiaxing University
2023
Wnt/β-catenin signaling plays a crucial role in cancer development, primarily activated by β-catenin forming transcription complex with LEF/TCF the nucleus and initiating of Wnt target genes. Here, we report that LEF1, member family, can form intrinsically disordered region (IDR)-dependent condensates both vivo vitro, which is required for β-catenin-dependent transcription. Notably, LEF1 disrupted IDR lost its promoting activity on tumor proliferation metastasis, be restored substituting FUS...
Abstract HIV-1 initiates replication by its transactivator Tat, hijacking the positive transcription elongation factor b (P-TEFb) in host cell. Most P-TEFb is maintained an inactive state 7SK snRNP until it brought to initiation complex cellular or viral transactivators that accelerate and facilitate production of full-length transcripts. Here, we report infection triggers liquid-liquid phase separation LARP7, a central component snRNP. Tat incorporated into HIV-1-induced LARP7 condensates...