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Olivia A. Swaim

ORCID: 0009-0004-8573-5440
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About
Contact & Profiles
A5092458671
Research Areas
  • Epigenetics and DNA Methylation
  • Prostate Cancer Treatment and Research
  • Histone Deacetylase Inhibitors Research
  • Cancer-related gene regulation

University of Michigan
 2023-2025

 LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function
OPENALEX - Publications 
Anbarasu Kumaraswamy Zhi Duan Diana Flores Chao Zhang Archana Sehrawat and 20 more Ya‐Mei Hu Olivia A. Swaim Eva S. Rodansky William K. Storck Joshua Agbemefa Kuleape Karan Bedi Rahul Mannan Xiaoming Wang Aaron M. Udager Visweswaran Ravikumar Armand Bankhead Ilsa M. Coleman John K. Lee Colm Morrissey Peter S. Nelson Arul M. Chinnaiyan Arvind Rao Zheng Xia Joel A. Yates Joshi J. Alumkal

Lysine-specific demethylase 1 (LSD1) is a histone that promotes stemness and cell survival in cancers such as prostate cancer. Most malignancies are adenocarcinomas with luminal differentiation. However, some tumors undergo cellular reprogramming to more lethal subset termed neuroendocrine cancer (NEPC) neuronal The frequency of NEPC increasing since the widespread use potent androgen receptor signaling inhibitors. Currently, there no effective treatments for NEPC. We previously determined...

10.1172/jci.insight.167440 article EN cc-by JCI Insight 2023-07-13
 LSD1+8a is an RNA biomarker of neuroendocrine prostate cancer
OPENALEX - Publications 
Anbarasu Kumaraswamy Rahul Mannan Olivia A. Swaim Eva S. Rodansky Xiaoming Wang and 10 more Aaron M. Udager Rohit Mehra Hui Li Colm Morrissey Eva Corey Michael Haffner Peter S. Nelson Arul M. Chinnaiyan Joel A. Yates Joshi J. Alumkal

10.1016/j.neo.2025.101151 article EN Neoplasia 2025-03-14
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