A5034948520- Tissue Engineering and Regenerative Medicine
- Cardiac Valve Diseases and Treatments
- Mesenchymal stem cell research
- Cardiovascular Function and Risk Factors
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Structural Anomalies and Repair
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Diagnosis and Treatment of Venous Diseases
- Aortic aneurysm repair treatments
- Coronary Artery Anomalies
- Cardiac Ischemia and Reperfusion
- Chemotherapy-induced cardiotoxicity and mitigation
- Venous Thromboembolism Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Pediatric Hepatobiliary Diseases and Treatments
- Pluripotent Stem Cells Research
- Ion channel regulation and function
- Infective Endocarditis Diagnosis and Management
- Cardiac Health and Mental Health
- Angiogenesis and VEGF in Cancer
Gifu Heart Center
2015-2025
National Hospital Organization
2006-2017
Utano Hospital
2017
Gifu University
2015
Yamagata Prefectural Shinjo Hospital
2015
Nagara Medical Center
2006-2009
Waseda University
2008
National Defense Academy of Japan
2007
National Cerebral and Cardiovascular Center
2002-2006
Auckland City Hospital
2005
Autologous bone marrow cells (BMCs) transplanted into ventricular scar tissue may differentiate cardiomyocytes and restore myocardial function. This study evaluated cardiomyogenic differentiation of BMCs, their survival in tissue, the effect implanted on heart function.BMCs from adult rats were cultured cell culture medium (control) with 5-azacytidine (5-aza, 10 micromol/L), TGFbeta1 (10 ng/mL), or insulin (1 nmol/L) (n=6, each group). Only BMCs 5-aza formed myotubules which stained...
Background —Autologous bone marrow cells (BMCs) transplanted into ventricular scar tissue may differentiate cardiomyocytes and restore myocardial function. This study evaluated cardiomyogenic differentiation of BMCs, their survival in tissue, the effect implanted on heart Methods Results —In vitro studies: BMCs from adult rats were cultured cell culture medium (control) with 5-azacytidine (5-aza, 10 μmol/L), TGFβ1 (10ng/mL), or insulin (1 nmol/L) (n=6, each group). Only 5-aza formed...
Little is known about the effect of heart cell transplantation into dilated cardiomyopathic myocardium. This study was designed to evaluate hamsters.Ventricular cells were isolated from 4-week-old BIO 53. 58 hamsters and cultured for 2 weeks before transplantation. The labeled with bromodeoxyuridine (BrdU) identification. Adult (17 old) used as recipients. Heart (4 x 10(6) cells) or culture medium transplanted left ventricular free wall (transplantation control groups, respectively, n=12...
A recent study showed that granulocyte-colony stimulating factor (G-CSF) treatment improved the infarcted cardiac function. Although mobilized stem cells may affect it, mechanism is unclear. In this study, we investigated origins of and phenotypic changes migrated cells, evaluated efficacy G-CSF. Eighteen C57BL/6 mice were irradiated (900 cGy) GFP mouse-derived bone marrow (GFP-BMC: 106 cells) injected via a tail vein followed by splenectomy 4 weeks later. Ligation left descending coronary...
これまで慢性静脈不全は局所の問題として扱われてきた.2021年Gutenberg Health Studyにて,高いCEAP分類は,元来心疾患を持っていない人が10年間に心臓血管病を発症する強力な予測因子であり,慢性静脈不全は全死亡の強力な予測因子であることが報告された.さらに共通危険因子に関して多くの報告がなされてきた.われわれは,胸部症状のない慢性静脈不全患者の35%が冠動脈カルシウムスコア100以上であり,慢性静脈不全が冠動脈カルシウムスコアの独立危険因子で無症候性虚血性心臓病のリスクであることを報告した.また慢性静脈不全が局所の問題ではなく,全身の浮腫へ影響することを報告した.慢性静脈不全はもはや足だけの問題ではなく心臓血管病と言える.啓蒙活動を含め動脈硬化リスク因子の検査,コントロールが必要である.そのためには足に関わる全医療関係者の協力が必要である.
Background Previous research has indicated a correlation between chronic venous insufficiency (CVI) and cardiovascular disease. However, whether CVI is an independent risk factor for coronary artery disease (CAD) remains underexplored. This study aimed to investigate this relationship by utilizing calcium score (CACS) assessment during screening comparing it with CACS in patients undergoing cardiac ablation treatment. Methods Subjects: A retrospective cohort was conducted, approved the...
Background The present study examined whether a bioengineered polyglycolic acid cloth (PGAC) impregnated with bone marrow cells (BMC) improved the function and angiogenesis of infarcted heart. Methods Results coronary artery was ligated in Lewis rats area covered PGAC group 1 (n=8), containing basic-fibroblast growth factor (b-FGF) 2 (n=11) b-FGF freshly isolated BMC 3 (n=10). In addition, derived from transgenic mice expressing green fluorescent protein (GFP)-BMC were seeded into PGAC,...
Objectives We explored the connection between varicose vein and edema, by investigating extracellular water ratio (E/T) using bioelectrical impedance analysis. Methods In a prospective cohort study 120 patients underwent surgery with fluid to total body E/T postop divided E/Tpreop (E/T ratio) measured composition analyzer. Edema was defined as ≥0.390. Seventy-nine received unilateral treatment, while 41 bilateral. p < .05 is statistically significant. Results Preoperatively, exhibited...
Background Several clinical trials are underway to determine whether autologous skeletal myoblast transplantation is an effective and safe therapeutic strategy for severe heart failure due myocardial infarction (MI). It remains unclear repeated implantation a feasible cell delivery method the infarcted myocardium. Methods Results Four weeks after coronary ligation, male syngeneic Lewis rats were assigned 3 treatment groups: episodes of myoblasts (6×106) (group I), bolus (18×106) II), or...
Peripartum cardiomyopathy (PPCM) is a disorder of unknown cause in which heart failure occurs during the peripartum period. A 32-year-old woman was diagnosed with PPCM 10 days after delivery. One month initial diagnosis, newly formed left ventricular (LV) apical thrombus revealed and warfarin started. week later, became mobile she underwent surgical thrombectomy. Warfarin restarted on postoperative day (POD) 1; however, thrombi recurred at POD 3. Intravenous heparin then supplemented,...
Abstract OBJECTIVES To compare different configurations of the bilateral internal thoracic arteries for left coronary system and examine early late outcomes, including mid-term graft patency. METHODS We reviewed 877 patients who underwent primary isolated artery bypass grafting using in situ [in right (RITA)-to-left anterior descending (LAD) grafting, n = 683; (LITA)-to-LAD 194]. compared patency between grafts. Propensity score matching was performed to investigate long-term outcomes....