A5087128015- Innovative Teaching Methods
- Synthesis and biological activity
- Click Chemistry and Applications
- Computational Drug Discovery Methods
- Various Chemistry Research Topics
- Biochemical and Structural Characterization
- Experimental Learning in Engineering
- Mobile Learning in Education
- Microbial Metabolites in Food Biotechnology
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Phytochemistry and Bioactive Compounds
- Machine Learning in Bioinformatics
- Evaluation of Teaching Practices
- Microbial Natural Products and Biosynthesis
- Bacterial Genetics and Biotechnology
University of California, Irvine
2020-2024
At University of California, Irvine, a large-enrollment research university, undergraduate chemistry courses for non-chemistry majors were delivered remotely during the 2020–2021 academic year, with return to in-person instruction planned January 2022. Because this coincided transition second-year students from general organic laboratory courses, instructional staff recognized need remedial curricula no prior experience. Simultaneously, we desired implement Learning Assistants (LAs) in major...
Multimedia approaches, including short instructional videos, are complementary to traditional modes of instruction such as in-person lecture and written procedures. We describe the creation implementation Quick Reference (QR) videos in an undergraduate organic chemistry laboratory (OCL) setting for non-chemistry majors. The QR were designed address specific, recurring questions about equipment, procedure, concepts that students our OCL courses find continually challenging. Quick-response...
Our laboratory reported the chemical synthesis and stereochemical assignment of recently discovered peptide antibiotic clovibactin. The current paper reports an improved, gram-scale amino acid building block Fmoc-(2R,3R)-3-hydroxyasparagine-OH that enables structure–activity relationship studies An alanine scan reveals residues Phe1, d-Leu2, Ser4, Leu7, Leu8 are important for activity. side-chain amide group rare d-Hyn5 residue is not essential to activity can be replaced with a methyl...
At a large-enrollment research university, undergraduate chemistry courses for non-chemistry majors were delivered remotely during the 2020–2021 academic year, with return to in-person instruction planned January 2022. Because this coincided transition of second-year students from general labs organic labs, instructional staff recognized need remedial laboratory curricula no prior experience. Simultaneously, we desired implement Learning Assistants (LAs) in major laboratories first time at...
This paper describes the structure-based design of a preliminary drug candidate against COVID-19 using free software and publicly available X-ray crystallographic structures. The goal this tutorial is to disseminate skills in allow others unleash their own creativity new drugs fight current pandemic. begins with structure main protease (M<sup>pro</sup>) SARS coronavirus (SARS-CoV) bound peptide substrate then uses UCSF Chimera modify create cyclic inhibitor within...
The unusual d-l-l-d-d-l-l pattern of stereochemistry in residues 1-7 the peptide antibiotic teixobactin is critical to its extraordinary activity, creating an amphiphilic β-sheetlike structure that essential mechanism action. current study sought replace three d-amino acids tail with l-amino while maintaining amphiphilicity. We find swapping d-Gln
Multimedia approaches, including short instructional videos, are complementary to traditional modes of instruction such as in-person lecture and written procedures. We describe the creation, implementation, evaluation Quick Reference (QR) videos in an undergraduate organic chemistry laboratory (OCL) setting for nonchemistry majors. The QR were designed address specific, recurring questions about equipment, procedure, concepts that students our OCL courses find continually challenging....
This paper describes the structure-based design of a preliminary drug candidate against COVID-19 using free software and publicly available X-ray crystallographic structures. The goal this tutorial is to disseminate skills in allow others unleash their own creativity new drugs fight current pandemic. begins with structure main protease (M pro ) SARS coronavirus (SARS-CoV) bound peptide substrate then uses UCSF Chimera modify create cyclic inhibitor within M active site. Finally, molecular...
This paper describes the structure-based design of a preliminary drug candidate against COVID-19 using free software and publicly available X-ray crystallographic structures. The goal this tutorial is to disseminate skills in allow others unleash their own creativity new drugs fight current pandemic. begins with structure main protease (M pro ) SARS coronavirus (SARS-CoV) bound peptide substrate then uses UCSF Chimera modify create cyclic inhibitor within M active site. Finally, molecular...