Sreelakshmi Krishnakumar

ORCID: 0009-0005-0043-0478
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About
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Research Areas
  • Graphene and Nanomaterials Applications
  • Nanoparticles: synthesis and applications
  • Mercury impact and mitigation studies
  • Microplastics and Plastic Pollution
  • Tracheal and airway disorders
  • Pregnancy and preeclampsia studies
  • Heavy Metal Exposure and Toxicity
  • Dysphagia Assessment and Management
  • Voice and Speech Disorders
  • Carbon and Quantum Dots Applications
  • Reproductive biology and impacts on aquatic species
  • Nanocluster Synthesis and Applications
  • Selenium in Biological Systems

Amrita Vishwa Vidyapeetham
2019-2024

Andover Eye Associates
2021

Vocal fold (VF) scarring, a complex problem in laryngology, results from injury and inflammation of the layered architecture VFs. The resultant voice hoarseness, for which successful therapeutic options are currently limited, affects patient's quality life. A promising strategy to reverse this disorder is use antifibrotic drugs. present study proposes novel microbead-embedded injectable hydrogel that can sustain release anti-fibrotic drug pirfenidone (PFD) vocal scarring. Microbeads were...

10.1021/acsabm.4c00422 article EN ACS Applied Bio Materials 2024-07-15

The inheritable impact of exposure to graphene oxide nanoparticles (GO NPs) on vertebrate germline during critical windows gamete development remain undetermined date. Here, we analyzed the transgenerational effects nano-graphene particles (nGO) synthesized in house with lateral dimensions 300–600 nm and surface charge −36.8 mV different developmental stages germ cells (GCs): (1) GCs undergoing early differentiation, (2) gametogenesis maturation adulthood. Biocompatibility analyses Japanese...

10.1080/17435390.2024.2325615 article EN Nanotoxicology 2024-02-17

This study investigated the adverse effects of 200 nm zinc oxide particles (nZnO) on sexual behavior and reproduction in Japanese medaka comparison with ZnSO4 correlated consequences bioaccumulation pattern associated organs. nZnO exposure impaired territorial behaviors affected fertility by altering sperm viability motility males through reactive oxygen species (ROS) induction. Conversely, none these other than loss was seen exposed to ZnSO4. females induced ROS ovaries, causing follicular...

10.1021/acsabm.1c00575 article EN ACS Applied Bio Materials 2021-10-04

Graphene quantum dots (GQDs) have emerged as promising biolabeling agents owing to their stable innate fluorescence, photostability, and biocompatibility opposed semiconductor dots. While several studies reported GQDs be cytocompatible, potential for reproductive toxicity, particularly germ cells that can cause transgenerational remains unexplored. Here we report the intrinsic toxicity of 2–3 nm sized synthesized from glucose by a novel bottom-up green chemistry technique on cell...

10.1021/acsabm.8b00606 article EN ACS Applied Bio Materials 2019-01-24

<img src=” https://s3.amazonaws.com/production.scholastica/article/29807/large/prnano_712021ga.jpg?1636618113”> Whitlockite, the second most abundant bone mineral, was found promising in regenerative engineering of damaged tissue because its high remodelling potential. However, no studies have investigated effects on other organ systems and environment. It is essential to study this aspect as whitlockite known dissolute at non-acidic pH. Hence, nanoparticles embryonic development, germ...

10.33218/001c.29807 article EN cc-by-nc Precision Nanomedicine 2021-11-03
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