A5103010527- Robotic Locomotion and Control
- Prosthetics and Rehabilitation Robotics
- Robot Manipulation and Learning
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- RNA regulation and disease
- Photonic Crystals and Applications
- Endoplasmic Reticulum Stress and Disease
- Liquid Crystal Research Advancements
- Transition Metal Oxide Nanomaterials
- Gas Sensing Nanomaterials and Sensors
- Catalytic Processes in Materials Science
- Plant Reproductive Biology
- Autophagy in Disease and Therapy
- Chemokine receptors and signaling
- Orthopedic Surgery and Rehabilitation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hormonal Regulation and Hypertension
- Immune cells in cancer
- Elbow and Forearm Trauma Treatment
- Neuropeptides and Animal Physiology
- Metabolism, Diabetes, and Cancer
- Bone fractures and treatments
- Epigenetics and DNA Methylation
Max Planck Institute for Heart and Lung Research
2025
National Health Research Institutes
2022-2023
Far Eastern Memorial Hospital
2023
National Taipei University of Technology
2023
National Cheng Kung University
2006-2020
National Changhua University of Education
2010
Insulin resistance is a hallmark of obesity-associated type 2 diabetes. Insulin’s actions go beyond metabolic cells and also involve blood vessels, where insulin increases capillary flow delivery nutrients. We show that adrenomedullin, whose plasma levels are increased in obese humans mice, inhibited signaling human endothelial through protein-tyrosine phosphatase 1B–mediated dephosphorylation the receptor. In mice lacking adrenomedullin receptor, insulin-induced nitric oxide–synthase...
Type 2 diabetes mellitus (T2DM) is a frequent comorbidity of cancer. Hyperinsulinemia secondary to T2DM promotes cancer progression, whereas antidiabetic agents, such as metformin, have anticancer effects. However, the detailed mechanism for insulin and metformin-regulated cell proliferation remains unclear. This study identified by which upregulated expression c-Myc, sterol regulatory element-binding protein 1 (SREBP1), acetyl-coenzyme A (CoA) carboxylase (ACC1), are important regulators...
The mechanism by which glioblastoma evades temozolomide (TMZ)-induced cytotoxicity is largely unknown. We hypothesized that mitochondria plays a role in this process. RNA transcriptomes were obtained from tumor samples and online databases. Expression of different proteins was manipulated using interference or gene amplification. Autophagic activity mitochondrial metabolism assessed vitro the respective cellular molecular assays. In vivo analysis also carried out study. High SH3GLB1...
This study presents design methodologies, specifications and control strategies for vision-guided object grasping the developed humanoid robot, Cheng-kung Humanoid RobotIc System (CHRIS). The robot constructed herein comprises mainly a wheeled mobile base, fixed torso mounted on two arms with seven Degrees of Freedom (DOF), hands DOF, one robotic binocular head five DOF. proposed eye/arm coordination structure is hybrid image-based/position-based look-and-move structure. Finally, experiment...
We investigate the switching characteristics of a silica nanoparticle-doped dual-mode liquid crystal (LC) display. In multistable mode, aggregated networks impede relaxation LCs and increase response time cell. A low-frequency AC pulse voltage rotates breaks networks. The breaking accelerates hence decreases gives cell fast ∼23 ms, which is ∼4% our previous result.
This study constructs a wheeled humanoid robot as our preliminary research of robots. The developed herein comprises mainly mobile base, fixed torso mounted on two 7 DOF arms, hands and one 5 robotic binocular head. A coordinated visually guided control structure is then proposed for this robot. Image processing algorithms are also to increase the perception capability rapidly detecting location target object in natural environment, thus reducing computational burden image processing....
Isolated capitate fractures are rare carpal fractures. Following high-energy injuries, usually associated with other or ligament injuries. The management of depends on the fracture pattern. Here, we report an unusual a dorsal shearing pattern and concomitant carpometacarpal dislocation, 6-year follow-up. To best our knowledge, this surgical have not been previously reported.A 28-year-old man presented left-hand volar tenderness decreased grip strength that persisted for one month after...
Glioblastoma (GBM), a malignant brain tumor, has poor survival outcomes due to recurrence or drug resistance. We found that SH3GLB1 is crucial factor for cells evade temozolomide (TMZ) cytotoxicity through autophagy-mediated oxidative phosphorylation, which associated with CD133 levels. Therefore, we propose participate in the impact on tumor-initiating (TICs).The parental, derived resistant cell lines and their CD133+ were used, levels of proteins compared by western blotting. Then RNA...