A5078530200- Genomics and Rare Diseases
- Chemical Reactions and Isotopes
- CRISPR and Genetic Engineering
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Magnesium Oxide Properties and Applications
- Parkinson's Disease Mechanisms and Treatments
- Protein Degradation and Inhibitors
- Cardiac electrophysiology and arrhythmias
- Hereditary Neurological Disorders
- vaccines and immunoinformatics approaches
- Copper-based nanomaterials and applications
- Genetics and Neurodevelopmental Disorders
- Computational Drug Discovery Methods
- Helicobacter pylori-related gastroenterology studies
- ZnO doping and properties
- Click Chemistry and Applications
University of Okara
2022-2024
Aarhus University
2024
King Saud University
2024
Lahore College for Women University
2023
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that interacts with TrkB and p75NTR receptors, playing crucial role in neuronal plasticity, differentiation, neurotransmission. The BDNF gene regulates glutamatergic GABAergic synaptic plasticity while influencing serotonergic dopaminergic pathways. Despite its biological significance, the structural functional properties of remain incompletely understood, posing challenge development therapeutic strategies. To address this,...
Single nucleotide polymorphisms are the most common form of DNA alterations at level a single in genomic sequence. Genome-wide association studies (GWAS) were carried to identify potential risk genes or regions by screening for SNPs associated with disease. Recent have shown that SCN9A comprises NaV1.7 subunit, Na + channels gene encoding 1988 amino acids arranged into 4 domains, all 6 transmembrane regions, and mainly found dorsal root ganglion (DRG) neurons sympathetic neurons. Multiple...
N-acetyltransferase 2, also known as arylamine N-acetyltransferase, commonly NAT2. The objective of this study was to identify non-synonymous SNPs NAT2 and their association with breast cancer using computational analysis. For purpose, different online tools like SIFT, Polyphen, Polyphen-2, fuNTRp, SNAP2 (to pathogenic SNPs), SNP&GO, PhD-SNP, PredictSNP, MAPP, SNAP, MetaSNP, PANTHER (disease associated Mu-Pro, I-Mutant, CONSURF check protein stability) were used. Post-translational...
<title>Abstract</title> Brain-derived neurotrophic factor, a protein belonging to the neurotrophin family, interacts with receptors known as TrkB and p75NTR that are present in nervous system. A <italic>BDNF</italic> gene is responsible for plasticity of glutamate, GABA synapses also influences differentiation neurons impacts serotonergic dopaminergic neurotransmission. The study executes comprehensive computational research on protein, assessing structural functional consequences by...
Genetic variations play a crucial role in disease pathogenesis and serve as key biomarkers SNP analysis. Alpha-synuclein (SNCA), presynaptic protein involved neuronal plasticity, is implicated Parkinson’s through its abnormal accumulation Lewy bodies mutations the α-synuclein gene. The nsSNPs are known to account for over 50% of genetic disorders, highlighting their importance molecular mechanisms underlying PD. In this study, sequence structure-based web tools were employed analyze SNCA...
Tumor necrosis factor-beta is also called lymphotoxin-alpha. The objective of this study was to identify non-synonymous SNPs TNF-beta and their association with gastric cancer using computational analysis. For purpose, different online tools like SIFT, Polyphen, Polyphen-2, fuNTRp, SNAP2 (to pathogenic SNPs), SNP&GO, PhD-SNP, PredictSNP, MAPP, SNAP, MetaSNP, PANTHER (disease associated Mu-Pro, I-Mutant, CONSURF check protein stability) were used. Post-translational modifications (PTMs)...