A5067581173- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Respiratory Support and Mechanisms
- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- Tuberculosis Research and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Heart Rate Variability and Autonomic Control
- Anesthesia and Sedative Agents
- Sepsis Diagnosis and Treatment
- Poisoning and overdose treatments
- Mycobacterium research and diagnosis
- Nitric Oxide and Endothelin Effects
- Family and Patient Care in Intensive Care Units
- Atherosclerosis and Cardiovascular Diseases
- Water Quality Monitoring Technologies
- Recycling and Waste Management Techniques
University of California, Davis
2023
University of California, Berkeley
2020-2021
Hospital Nacional de Niños
2006
Universidad de Costa Rica
2004
Tuberculosis consistently causes more deaths worldwide annually than any other single pathogen, making new effective vaccines an urgent priority for global public health. Among potential adjuvants, STING-activating cyclic dinucleotides (CDNs) uniquely stimulate a cytosolic sensing pathway activated only by pathogens. Recently, we demonstrated that CDN-adjuvanted protein subunit vaccine robustly protects against tuberculosis infection in mice. In this study, delineate the mechanistic basis...
Background: Among patients with heart failure (HF) reduced ejection fraction (HFrEF), a subpopulation improves ventricular function, HF improved (HFimpEF). This study aimed to investigate the longitudinal remodeling trajectories associated HFimpEF and HFrEF. Methods: was retrospective cohort study, UC Davis Medical Center (2014 2022). The inclusion criteria included related ICD codes, left (LVEF) ≤40%, B-type natriuretic peptide (BNP) ≥100 pg/mL. Longitudinal BNP echocardiographic data were...
Abstract Background Heart failure (HF) with improved ejection fraction (HFimpEF) has better outcomes than HF reduced (HFrEF). However, factors contributing to HFimpEF remain unclear. This study aimed evaluate clinical and longitudinal characteristics associated subsequent HFimpEF. Methods was a single-center retrospective HFrEF cohort study. Data were collected from 2014 2022. Patients identified using ICD codes, echocardiographic data, natriuretic peptide levels. The main endpoints (defined...
Abstract The only licensed vaccine for tuberculosis, Mycobacterium bovis Bacille Calmette-Guérin (BCG), is not reliably effective against adult pulmonary tuberculosis. A major hurdle to tuberculosis development incomplete understanding of successful immunity the causative agent . Recently, we demonstrated that a protein subunit adjuvanted with STING-activating cyclic-di-nucleotides (CDNs) robustly protects infection in mice. Here show mucosal vaccination this induces production T cells home...
Abstract Tuberculosis (TB) is the top infectious killer in world. The only current licensed vaccine for TB, Mycobacterium bovis Bacille Calmette-Guérin (BCG), has not proven reliably effective against adult pulmonary TB all studies. It furthermore cannot be administered safely to immunocompromised individuals as it a live attenuated vaccine. Protein subunit vaccines offer increased safety over vaccines. Many recently developed protein use toll-like receptor-stimulating adjuvants that induce...