A5096521328- Hip disorders and treatments
- Shoulder Injury and Treatment
- Total Knee Arthroplasty Outcomes
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Orthopaedic implants and arthroplasty
- Text Readability and Simplification
- Cardiovascular Syncope and Autonomic Disorders
- Glioma Diagnosis and Treatment
- Neuroscience and Music Perception
- Hormonal Regulation and Hypertension
- Shoulder and Clavicle Injuries
- Psychological and Temporal Perspectives Research
- Cancer, Stress, Anesthesia, and Immune Response
- Dietary Effects on Health
- Neural dynamics and brain function
Yale University
2025
Yale New Haven Hospital
2025
Washington University in St. Louis
2024
Studies of human perception have shown early cortical signals for primary information encoding, and later higher order processing. An important late signal is the event-related desynchronization (ERD) in alpha (8-12Hz) beta (12-30Hz) frequency band, which has been linked to perceptual awareness. Detailed mechanistic investigation ERD would be greatly facilitated by availability a suitable animal model. We conducted local field potential recordings mouse frontal association cortex (FrA),...
Abstract Introduction: The American Medical Association recommends that healthcare articles intended for the public should be written at or below a sixth grade reading level. literature has consistently shown online materials on orthopedic surgeries are level well above this threshold. This discrepancy can exacerbate existing disparities, as patients with lower education language barriers may unable to fully understand implications of surgical procedure and postoperative protocol. study...
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with a poor prognosis despite aggressive therapy. Here, we hypothesized that daily host signaling regulates growth and synchronizes circadian rhythms GBM. We find glucocorticoids promote or suppress GBM through glucocorticoid receptor (GR) depending on time of day clock genes, Bmal1 Cry. Blocking signals, like vasoactive intestinal peptide glucocorticoids, dramatically slows disease progression. Analysis human...
Glioblastoma (GBM) is the most common primary brain tumor in adults with a poor prognosis despite aggressive therapy. A recent, retrospective clinical study found that administering Temozolomide morning increased patient overall survival by 6 months compared to evening. Here, we tested hypothesis daily host signaling regulates growth and synchronizes circadian rhythms GBM. We Dexamethasone promoted or suppressed GBM depending on time of day administration clock gene,