A5013932562- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Dementia and Cognitive Impairment Research
- Neurogenetic and Muscular Disorders Research
- Lymphoma Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Lung Cancer Treatments and Mutations
- Genetic Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Dialysis and Renal Disease Management
- Neuroendocrine Tumor Research Advances
- Long-Term Effects of COVID-19
- Lung Cancer Research Studies
- Acupuncture Treatment Research Studies
- Chronic Kidney Disease and Diabetes
- Inflammasome and immune disorders
- PARP inhibition in cancer therapy
- Pharmacology and Obesity Treatment
- Colorectal Cancer Treatments and Studies
- Neurological and metabolic disorders
- Ureteral procedures and complications
Southern Medical University
2024
The University of Sydney
2017-2024
First Hospital of China Medical University
2024
China Medical University
2024
Chinese PLA General Hospital
2022-2023
University of Electronic Science and Technology of China
2022-2023
Fujian Medical University
2023
Chinese People's Liberation Army
2022
State Key Laboratory of Kidney Diseases
2022
Guangdong Medical College
2022
Objective: To conduct a meta-analysis of current studies that examined sex differences in severity and mortality patients with COVID-19, identify potential mechanisms underpinning these differences. Methods: We performed systematic review to collate data from observational examining associations clinical outcomes COVID-19. PubMed, Web Science four preprint servers were searched for relevant studies. Data extracted analyzed using where possible, summary presented otherwise. Publicly available...
Abstract Aims Although the orally available brain‐penetrant copper compound CuATSM has demonstrated promising effects in SOD1‐linked mouse models, impact of on disease pathology patients with amyotrophic lateral sclerosis (ALS) remains unknown. Methods The present study set out to address this deficit by performing first pilot comparative analysis ALS that had been administered and riluzole [ N = 6 cases composed ALS‐TDP ( n 5) ALS‐SOD1 1)] versus only 4) 2)]. Results Our results revealed no...
Abstract Introduction The diagnostic utility of in vivo amyloid β (Aβ) imaging to aid the clinical distinction between frontotemporal dementia (FTD) and Alzheimer's disease remains unclear without data on prevalence severity Aβ pathologically confirmed FTD syndromes. Methods was assessed 98 autopsy‐confirmed 36 control cases, pathological accuracy 11 C‐Pittsburgh compound B (PiB)–positron emission tomography a subset cases ( n = 15). Results identified similar proportion syndromes...
The identification of the TAR DNA-binding protein 43 (TDP-43) as ubiquitinated cytoplasmic inclusions in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) confirmed that these two diseases share similar mechanisms, likely to be linked abnormal hyperphosphorylation, ubiquitination cleavage pathological TDP-43. Importantly however, a quantitative analysis TDP-43 predilection cortical regions FTLD, FTLD-ALS ALS cases has not been undertaken. present study set out...
Abstract Background Multiple system atrophy (MSA) is a neurodegenerative disease pathologically characterized by the presence of glial cytoplasmic inclusions (GCI) composed α‐synuclein aggregates. In Parkinson's disease, increases in monounsaturated fatty acids (MUFA) phospholipid membranes promote binding, aggregation, and toxicity, inhibition stearoyl‐CoA desaturase (SCD), enzyme responsible for synthesizing MUFA, alleviates toxicity. However, little known about MUFA or SCD context MSA...
Background: The early and selective loss of von Economo neurons in the anterior cingulate cortex has been linked to behavioral deficits frontotemporal dementia (FTD). Importantly, whether these are also targeted patients with C9ORF72 repeat expansion yet be established. Thi s is particular interest given recent evidence highlighting thalamus rather than as a region significant degeneration expansion. Objective: To assess neuron density volumes variant FTD (bvFTD) cases expansion, sporadic...
To assess the amount of phosphorylated and nonphosphorylated TAR DNA-binding protein 43 (TDP-43) in motor brain regions cases amyotrophic lateral sclerosis (ALS) with without repeat expansions ATXN2 or C9ORF72 genes.The 45-kDa form TDP-43 43-kDa were quantified by immunoblot postmortem tissue from cortex, spinal cord, cerebellar vermis 23 ALS genes sporadic disease 10 controls.Significantly greater levels identified cortex expansions, significantly amounts found cord intermediate expansions....
Abstract Rare, yet biologically critical, lipids that contain very long chain fatty acids (VLCFA-lipids) are synthesized in the brain by enzyme ELOVL4. High levels of VLCFA-lipids toxic to cells and excess actively removed ABCD1 an ATP-dependent manner. Virtually nothing is known about impact neurodegenerative diseases. Here, we investigated possible role frontotemporal dementia (FTD), which a leading cause younger-onset dementia. Using quantitative discovery lipidomics, identified three...
The past decade has seen a surge in studies identifying mixed pathologies elderly populations. Importantly however, few have focussed on pathology Frontotemporal Lobar Degeneration (FTLD), particularly younger cases.The present study examined concomitant pathological neuronal inclusions of TDP-43, hyperphosphorylated tau and α-synuclein protein the anterior cingulate, hippocampus entorhinal cortex young (≤65 years at death) vs. (≥80 cases with pathologically confirmed FTLD (n = 52) or...
Abstract Background Breast cancer patients undergoing chemotherapy via peripherally inserted central catheter often experience serious behavioral and psychological challenges, with uncertainty cancer-related fatigue being prevalent issues that profoundly impact prognosis. Therefore, this study aimed to investigate the relationship between by employing a chain mediation model examine potential mediating roles of resilience self-care. Methods A cross-sectional was conducted 223 breast...
The selective loss of von Economo neurons has been linked to the behavioral deficits in variant frontotemporal dementia (bvFTD) but whether these are affected bvFTD patients with underlying Alzheimer's disease (AD) yet be established. present study assesses pathological AD cases clinically diagnosed either or bvFTD. Our results demonstrate no significant all cases, irrespective clinical diagnosis co-existing Lewy body pathology. These suggest that and not driven by neurons.