A5039512812- Parkinson's Disease Mechanisms and Treatments
- Visual perception and processing mechanisms
- Spatial Neglect and Hemispheric Dysfunction
- Botulinum Toxin and Related Neurological Disorders
- Gaze Tracking and Assistive Technology
- Dementia and Cognitive Impairment Research
- Neurological disorders and treatments
- Neurogenetic and Muscular Disorders Research
- Advanced Neuroimaging Techniques and Applications
- Amyotrophic Lateral Sclerosis Research
- Ergonomics and Musculoskeletal Disorders
- Autoimmune Bullous Skin Diseases
- Digital Mental Health Interventions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ophthalmology and Eye Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Viral Infections and Immunology Research
- Urban and spatial planning
- Zebrafish Biomedical Research Applications
- Cerebral Palsy and Movement Disorders
- Myasthenia Gravis and Thymoma
- Balance, Gait, and Falls Prevention
- Hearing, Cochlea, Tinnitus, Genetics
- Animal Virus Infections Studies
Osaka University
2020-2025
Molina Center for Energy and the Environment
2025
Tokyo University of Agriculture and Technology
2019
Background and Objective: Dementia with Lewy bodies (DLB) is frequently misdiagnosed as Alzheimer's disease (AD) due to overlapping clinical presentations. In this study, we evaluated a smartphone-based digital platform that leverages behavioral markers accurately differentiate between DLB AD. Methods: We conducted cross-sectional study on 81 participants (Healthy controls = 40, AD 21, 20), administering MMSE, noise pareidolia test (NPT) integrated eye-tracking speech inputs. Ground truth...
BACKGROUND AND OBJECTIVE: Dementia with Lewy bodies (DLB) is frequently misdiagnosed as Alzheimer’s disease (AD) due to overlapping clinical presentations. In this study, we evaluated a smartphone-based digital platform that leverages behavioral markers accurately differentiate between DLB and AD. METHODS: We conducted cross-sectional study on 81 participants (Healthy controls = 40, AD 21, 20), administering the MMSE noise pareidolia test (NPT) integrated eye-tracking speech inputs. Ground...
Abstract Pareidolias refer to visual perceptual deficits where ambiguous shapes take on meaningful appearances. In neurodegenerative diseases, pareidolias are examined via a paper-based neuropsychological tool called the noise pareidolia test. this study, we present initial findings regarding utilization of test digital format analyze variations between and testing approaches. We performed our experiments healthy controls, patients diagnosed with Alzheimer’s disease (AD), Dementia Lewy body...
Freezing of gait is one the most disturbing motor symptoms Parkinson's disease (PD). However, effective connectivity between key brain hubs that are associated with pathophysiological mechanism freezing remains elusive.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease; transactivation response DNA-binding protein of 43 kDa (TDP-43) and iron accumulation are supposed to play crucial role in the pathomechanism disease. Here, we report an unusual case patient with ALS who presented speech apraxia as initial symptom upper motor neuron deficiencies. In early clinical stages, single-photon emission computed tomography visualized focal hypoperfusion right frontal operculum, magnetic...
Abstract Objective This study aimed to develop a Japanese version of the New Freezing Gait Questionnaire (NFOG-Q) and investigate its validity reliability. Methods After translating NFOG-Q according standardised protocol, 56 patients with Parkinson’s disease (PD) were administered it. Additionally, MDS-UPDRS parts II III, Hoehn Yahr (H&Y) stage, number falls over 1 month evaluated. Spearman’s correlation coefficients (rho) used determine construct validity, Cronbach’s alpha (α) was...
Abstract Pareidolias are illusionary phenomena wherein ambiguous forms appear meaningful. In clinical research, pareidolias have been studied using paper or desktop test formats to deconstruct visuo-perceptual mechanisms. Translating this work on an accessible, scalable setup such as smartphones is currently unknown. Here, we designed a smartphone-based pareidolia study visual processes affecting gaze behavior of cognitively healthy individuals standard, native front-facing camera. We...
Pareidolias refer to visual perceptual deficits where ambiguous shapes take on meaningful appearances. In neurodegenerative diseases, pareidolias are examined via a paper-based neuropsychological tool called the noise pareidolia test. this study, we present initial findings regarding utilization of test digital format analyze variations between and testing approaches. We performed our experiments healthy controls, patients diagnosed with Alzheimer's disease (AD), Dementia Lewy body (DLB)...
Recently, the common marmoset (Callithrix jacchus) has attracted significant interest as a non-human primate stroke model. Functional impairment in models should be evaluated quantitatively and successively after stroke, but conventional observational assessments of behavior cannot fully fit this purpose. In paper, we report behavioral analysis using MarmoDetector, three-dimensional motion analysis, an ischemic model photosensitive dye, along with assessment imaging examination.Ischemic was...
We herein report a 56-year-old Japanese woman who had been diagnosed with hereditary angioedema. She experienced progressing muscle weakness and pain in the upper lower extremities. Blood tests revealed marked increase creatine kinase levels; however, myositis-specific autoantibodies were not detected. Serum C1-inhibitor activity C4 levels low. A biopsy showed mild fiber necrosis C5b-9 deposition endomysial capillary vessel walls sarcolemma, mimicking necrotizing myopathy. These results...