A5037337179- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Pregnancy and preeclampsia studies
- Reproductive tract infections research
- Endometriosis Research and Treatment
- Pregnancy and Medication Impact
- Maternal and fetal healthcare
- Adolescent Sexual and Reproductive Health
- Immune Response and Inflammation
- Pregnancy-related medical research
- Neurogenesis and neuroplasticity mechanisms
- Urinary Tract Infections Management
- Curcumin's Biomedical Applications
- Herpesvirus Infections and Treatments
- Electrolyte and hormonal disorders
- Cancer Cells and Metastasis
- Prenatal Screening and Diagnostics
- Syphilis Diagnosis and Treatment
- Animal Genetics and Reproduction
- Circular RNAs in diseases
- COVID-19 and healthcare impacts
- Birth, Development, and Health
- Cancer Risks and Factors
- Grief, Bereavement, and Mental Health
- Reproductive Biology and Fertility
University of Oxford
2023-2024
McMaster University
2018-2021
McMaster University Medical Centre
2018-2020
Queen's University
2013-2017
Herpes Simplex Virus Type 2 (HSV-2) is one of the most prevalent sexually transmitted viruses and a known risk factor for HIV acquisition in Female Genital Tract (FGT). Previously, we found that curcumin can block HSV-2 infection abrogate production inflammatory cytokines chemokines by genital epithelial cells vitro. In this study, investigated whether curcumin, encapsulated nanoparticles delivered various vivo routes, could minimize inflammation prevent or reduce FGT. mice were pre-treated...
The hormonal contraceptive medroxyprogesterone acetate (MPA) is associated with increased risk of human immunodeficiency virus (HIV), via incompletely understood mechanisms. Increased diversity in the vaginal microbiota modulates genital inflammation and HIV-1 acquisition. However, effect MPA on relatively unknown. In a cohort female Kenyan sex workers, negative for sexually transmitted infections (STIs), Nugent scores <7 (N=58 370 screened), correlated significantly as assessed by 16S rRNA...
Mice ablated for the gene encoding transcription factor Nfil3 lack peripheral natural killer (NK) cells but retain tissue-resident NK cells, particularly in mucosal sites, including virgin uterus. We undertook a time course histological study of implantation sites from syngeneically (Nfil3(-/-)) and allogeneically (BALB/c) mated Nfil3(-/-) females. also examined Rag2(-/-)Il2rg(-/-) females preconditioned by adoptive transfer marrow or uterine cell suspensions to identify pregnancy...
Abstract The decidua basalis of developing mouse implantation sites is highly enriched in CD45+ leukocytes. In intact, syngeneically mated C57BL/6 examined at gestation day 8.5 by whole-mount situ immunohistochemistry, leukocyte, but not trophoblast, conjugations were reported. Nothing known regarding time course, frequency, composition, or importance physiologic decidual cell pairing. this study, we confirmed the presence anti-CD54+/anti-CD11a+ immune synapses conjugates and characterized...
Abstract The progestin-based hormonal contraceptive Depot Medroxyprogesterone Acetate (DMPA) is widely used in sub-Saharan Africa, where HIV-1 endemic. Meta-analyses have shown that women using DMPA are 40% more likely than not contraceptives to acquire Human Immunodeficiency Virus (HIV-1). Therefore understanding how increases susceptibility an important public health issue. Using C57BL/6 mice and our previously optimized humanized mouse model ( NOD-Rag1 tm1Mom Il2rg tm1Wjl transplanted...
Abstract Abnormally increased angiotensin II activity related to maternal angiotensinogen (AGT) genetic variants, or aberrant receptor activation, is associated with small-for-gestational-age babies and abnormal uterine spiral artery remodeling in humans. Our group studies a murine AGT gene titration transgenic (TG; 3-copies of the gene) model, which has 20% increase expression mimicking common human variant (A[−6]G) intrauterine growth restriction (IUGR) pathology. We hypothesized that...
Herpes simplex virus type 2 (HSV-2) infection affects 24 million births annually and is associated with adverse pregnancy outcomes, including neonatal herpes; however, the mechanisms underlying in utero transmission of HSV-2 are largely unknown. We examined effects primary during early on gestational outcomes a novel, clinically relevant mouse model. Pregnant C57BL/6 mice were infected intravaginally 102–105 pfu/mL gestation day (gd) 4.5. Controls infected, nonpregnant, diestrus-staged...
Mammalian pregnancy is a unique immunologic situation in which the maternal immune system recognizes and accepts an antigenically disparate tissue, conceptus. Currently, our understanding of human peri-implantation early gestational events largely based on animal studies, particularly mice. Although cells are present uterus before conception or blastocyst implantation, huge increases cell numbers differentiation specialized lymphocyte subsets induced species with hemochorial placentation...
The eleventh annual MBRRACE-UK report from the UK and Ireland Confidential Enquiries into Maternal Deaths Morbidity includes surveillance data on women who died during pregnancy or up to 1 year after between 2020 2022 in United Kingdom.1 Following topic-specific format, also care of this same period Kingdom thrombosis thromboembolism malignancies as well a result ectopic 2021 2022. Enquiry migrant arrived less than 2 years prior giving birth had preferred language other English. These were...
Abstract: The hormonal contraceptive Medroxyprogesterone Acetate (MPA) is associated with increased risk of Human Immunodeficiency Virus (HIV), via incompletely understood mechanisms. Increased diversity in the vaginal microbiota modulates genital inflammation and HIV-1 acquisition. However, effect MPA on relatively unknown. In a cohort female Kenyan sex workers, negative for sexually transmitted infections (STIs), Nugent Scores <7 (N=58 370 screened), correlated significantly as assessed...