A5052484298- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Inflammasome and immune disorders
- Schizophrenia research and treatment
- Drug-Induced Hepatotoxicity and Protection
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Essential Oils and Antimicrobial Activity
- Protein Degradation and Inhibitors
- Ginger and Zingiberaceae research
- Circadian rhythm and melatonin
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammation biomarkers and pathways
- Seaweed-derived Bioactive Compounds
- Gut microbiota and health
- Gene Regulatory Network Analysis
- Traditional Chinese Medicine Analysis
- Drug Transport and Resistance Mechanisms
- Treatment of Major Depression
- Inflammatory Bowel Disease
- Diabetes and associated disorders
- Mental Health and Psychiatry
- Pharmacogenetics and Drug Metabolism
- Phytochemistry and Bioactivity Studies
- Monoclonal and Polyclonal Antibodies Research
Shanghai Ocean University
2024
Beijing Graphene Institute
2024
BGI Research
2024
Nankai University
2024
Beijing HuiLongGuan Hospital
2001-2008
Huazhong University of Science and Technology
2006-2008
Doxorubicin (DOX) is a powerful anthracycline antineoplastic drug used to treat wide spectrum of tumors. However, its clinical application limited due cardiotoxic side effects. Astragaloside IV (AS IV), one the major compounds present in aqueous extracts Astragalus membranaceus, possesses potent cardiovascular protective properties, but underlying molecular mechanisms are unclear. Thus, aim this study was investigate effect AS on DOX-induced cardiotoxicity (DIC). Our findings revealed that...
The purpose of this study was to compare the efficacy and safety risperidone haloperidol in treatment-resistant chronic schizophrenic patients. Subjects (n = 78) who met DSM-III criteria for schizophrenia were randomly assigned receive 6 mg/day or 20 12 weeks. Clinical determined using Positive Negative Syndrome Scale (PANSS), side-effects with Treatment Emergent Symptom (TESS). Risperidone produced a mean 39.8 ± 24.1% reduction total PANSS score compared 28.3 19.4% group (P < 0.05)....
Interaction between epidermal growth factor (EGF) and EGF receptor (EGFR) promotes cell in most lines, but a number of paradoxically inhibits proliferation. In the present study, we established line expressing full-length human EGFR on membrane with GFP fluorescence reporter at C-terminal studied effects proliferation transfected line. Our results suggested that low concentrations promoted proliferation, while high induced loss adhesion, cycle arrest, apoptosis, inhibition The correlated...
This study explored the comorbid mechanisms between Crohn's disease (CD) and chronic obstructive pulmonary (COPD) using bioinformatics analysis. From Gene Expression Omnibus (GEO) microarray dataset, 349 common differentially expressed genes (coDEGs) were identified, 8 shared hub found: CCL2, CXCL1, TLR2, ICAM1, PTPRC, ITGAX, PTGS2, MMP9, which vital for immune function regulation of inflammatory responses. In addition, also analyzed association coDEGs cell infiltration single-sample gene...
This article aimed to fabricate Chondrus ocellatus polyphenols (COPs)-gelatin-chitosan nanoparticles enhance their stability and bioactivity. Different preparation conditions were tested investigate the effects of formulation on nanoparticle fabrication. Free radical scavenging activity COPs compared. The consequences revealed that optimal was obtained with a chitosan (CS) concentration 0.5 mg/mL, gelatin (Gel) 1.0 5.0 Gel-CS-COPs mass ratio 2:1:1. resultant had particle size 39.79 ± 5.15 nm...
Abstract The application and evaluation of single cell foundational models (scFMs) present significant challenges stemming from the heterogeneity architectural frameworks coding standards. To address these issues, we introduce BioLLM, a framework facilitating integration scFMs in single-cell RNA sequencing data analysis. BioLLM provides universal interface, bridging diverse into seamless ecosystem. By mitigating disparities conventions, it empowers researchers with streamlined access to...