A5103163586- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Vestibular and auditory disorders
- Cellular Mechanics and Interactions
- Ultrasound and Hyperthermia Applications
- Trauma Management and Diagnosis
- 3D Printing in Biomedical Research
- Cerebral Venous Sinus Thrombosis
- Polymer Surface Interaction Studies
- Nonmelanoma Skin Cancer Studies
- Wound Healing and Treatments
- Xenotransplantation and immune response
- Hydrogels: synthesis, properties, applications
- Immune Cell Function and Interaction
- Innovative Teaching Methods
- Ophthalmology and Eye Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Glycosylation and Glycoproteins Research
- Various Chemistry Research Topics
- Cervical and Thoracic Myelopathy
- Gynecological conditions and treatments
- Shoulder and Clavicle Injuries
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Hemoglobin structure and function
- Ultrasound and Cavitation Phenomena
Harvard University
2024-2025
ETH Zurich
2024-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019-2024
Swiss Federal Laboratories for Materials Science and Technology
2024
Klinikum Bielefeld
2020-2021
Université Sorbonne Nouvelle
2017
University Hospital of Basel
2008
Ruhr University Bochum
2008
University Children’s Hospital Basel
2008
University Hospital Bonn
2008
Objective: To compare muscle imaging findings in different subtypes of myofibrillar myopathies (MFM) order to identify characteristic patterns alterations that may be helpful separate these genetic heterogeneous muscular disorders. Methods: Muscle and clinical 46 patients with MFM were evaluated (19 desminopathy, 12 myotilinopathy, 11 filaminopathy, 1 αB-crystallinopathy, 3 ZASPopathy). The data collected retrospectively 43 prospectively patients. Results: In the semitendinosus was at least...
Artificial antigen-presenting cells (aAPCs) are currently used to manufacture T for adoptive therapy in cancer treatment, but a readily tunable and modular system can enable both rapid cell expansion control over phenotype. Here, it is shown that microgels with tailored surface biochemical properties serve as aAPCs mediate activation expansion. Surface functionalization of achieved via layer-by-layer coating using oppositely charged polymers, forming thin dense polymer layer on the surface....
Abstract The pain‐free monitoring of blood‐based biomarkers is essential for early detection diseases like cancers, infections, and metabolic disorders such as diabetes. While research often focuses on venous blood analysis, menstruation an overlooked but promising source. Evidence shows a strong correlation between biomarker levels in many clinical analytes. A wearable, microfluidic platform integrated into hygiene pads presented electronic‐free, naked‐eye disease (MenstruAI)....
Female sterilization via fallopian tube ligation is a common procedure; However, after the operation, over 10% of women seek re-fertilization, which frequently unsuccessful. In addition, there evidence that tubes contribute to spread endometriotic tissue as they serve channels for proinflammatory media entering abdominal cavity retrograde menstruation. Here, stimuli-degradable hydrogel implants are presented functional, biocompatible, and reversible occlusion tubes. The implants, designed...
ABSTRACT The pain-free regular monitoring of blood-based biomarkers is a highly appealing yet difficult-to-realize approach for the early detection pathological changes, including cancers, infections, or metabolic diseases, such as diabetes. While major focus research community lies on investigation blood sampling and devices venous analysis, menstruation remains largely ignored source. Growing evidence shows excellent correlation between biomarker levels in an entire clinical panel...
Abstract Drug-loaded magnetic nanoparticles (MNPs) accumulated by an external field already showed their efficacy in localized tumor treatment animal studies. Furthermore, specific MNPs are sonosensitive, enabling them to generate inertial cavitation when exposed a focused ultrasound field. This can be used for controlling drug release, as well particle detection and mapping. In addition cavitation, stable is also part of the process, which has not yet been evaluated on MNPs. While less...
Mutations in the Des gene coding for muscle-specific intermediate filament protein desmin lead to myopathies and cardiomyopathies. We previously generated a R349P knock-in mouse strain as patient-mimicking model corresponding most frequent human mutation R350P. Since nothing is known about age-dependent changes biomechanics of affected muscles, we investigated passive active small fiber bundles from young (17-23 wks), adult (25-45 wks) aged (>60 heterozygous homozygous mice comparison...
A new investigative physiology laboratory course was adopted for biology majors a few years ago. It is 2-credit, stand-alone, and research-based course. Physiological color change in lower vertebrates chosen the main theme of class research. Two major accomplishments this newly developed lab were 1) students seemed more actively engaged most experiments, 2) ownership tangibly exhibited their group research projects. One challenges we faced, however, quality student projects, which bit...
Abstract Muscle biomechanics is determined by active motor-protein assembly and passive strain transmission through cytoskeletal structures. The extrasarcomeric desmin filament network aligns myofibrils at the z-discs, provides nuclear-sarcolemmal anchorage may also serve as memory for muscle repositioning following large strains. Our previous analyses of R349P knock-in mice, an animal model human R350P desminopathy, already depicted pre-clinical changes in myofibrillar arrangement increased...
Die ventrale HWS Spondylodese ist eine gängige Methode zur Stabilisierung der Halswirbelsäule bei verschiedenen Pathologien (Instabilität Frakturen, Dislokationen, degenerative Veränderung). Komplikationen in Form von Schluckbeschwerden mit Fremdkörpergefühl, Hals-und Thoraxschmerzen auf Grund dislozierter Schrauben treten selten auf. Des Weiteren sind folgende beschrieben: Liquorleckage, wiederkehrende Kehlkopfverletzungen, pharyngoesophageale Verletzungen, prävertebraler Abszesse,...
The anterior cervical spine fusion is a common method to stabilize the in various pathologies (instability fractures, dislocations, degenerative change). Complications form of dysphagia with foreign body sensation, neck and chest pain due dislodged screws are rare. following complications also described: liquor leakage, recurrent laryngeal injuries, pharyngoesophageal pre-vertebral abscesses, airway obstruction, mediastinitis rupture carotid artery.
Bei Patient mit vestibulo-cochleärer Störung kann eine obere Bogengangsdehizsenz ursächlich für die beklagten Beschwerden sein. Dabei ist der Bogengang, sehr selten hintere oder horizontale, nur unzureichend Knochen bedeckt, sodass Verbindung zum Schädelinneren herrscht. Es entstehen veränderte Schalldruckbedinungen, zu einer normalen Labyrinthfunktion führt. wird auch von dem Syndrom des dritten Fensters gesprochen.