A5055025524- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Health, Environment, Cognitive Aging
- Health and Conflict Studies
- Disaster Management and Resilience
- COVID-19 and healthcare impacts
- Disaster Response and Management
- Healthcare Systems and Challenges
- Molecular Biology Techniques and Applications
- Fire effects on ecosystems
- Digital Imaging for Blood Diseases
- Botulinum Toxin and Related Neurological Disorders
- Traumatic Brain Injury Research
- Immunotoxicology and immune responses
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Risk Perception and Management
- Diversity and Career in Medicine
- Spatial Neglect and Hemispheric Dysfunction
University of California, San Diego
2021-2024
Vanderbilt University Medical Center
2023
Cardiff University
2023
Cardiff and Vale University Health Board
2021
La Trobe University
2021
AstraZeneca (United Kingdom)
2013
Image analysis is now routinely employed as a tool in toxicologic pathology to help quantitate end points of efficacy and safety. It regarded proficient sensitive technique generate numerical data that can be easily interrogated for statistical evaluation. Traditional semiquantitative scoring on the other hand sometimes less accurate due limitations systems day-to-day variations often noted between pathologists. We therefore decided an optimized histochemical staining image protocol compare...
Abstract Background As a response to the acute strain placed on National Health Service during first wave of coronavirus disease 2019 in UK, number junior doctors including ENT trainees were redeployed other clinical specialties. This presented these with novel challenges and opportunities. Methods A qualitative study was performed explore experiences, undertaking semi-structured interviews between 17th 30th July. Participants recruited through purposeful sampling. Interview transcripts...
To reduce the number of avoidable deaths from malaria in Britain following five points are recommended. Parliament should pass a Malaria Prevention Act that compels travel agents and airlines to give written verbal advice on prevention diagnosis people travelling countries where disease occurs. improve diagnostic therapeutic efficiency for all diseases Department Health Social Security prepare procedure manual NHS gives guidance doctors other medical staff. Avoidable be subject open...
Cognitive decline is an important early sign in pre-motor manifest Huntington's disease (preHD) and characterized by deficits across multiple domains including executive function, psychomotor processing speed, memory retrieval. Prior work suggested that the Loewenstein-Acevedo Scale for Semantic Interference Learning (LASSI-L)-a verbal learning task simultaneously targets these - could capture cognitive changes preHD. The current study aimed to replicate, validate further analyze LASSI-L...
Joy Drohan S1 mon solution for weight loss in HD-high calorie supplements-are generally disliked and not well tolerated, with the majority of prescriptions discarded rather than being consumed.Therefore, use Doddlebags represents a that allows patients to continue eating normal food on their own terms, minimal wastage much reduced cost National Health Service.
ABSTRACT Background Individuals with Huntington's disease (HD) experience motoric, cognitive, and psychiatric dysfunction. These difficulties can cause maladaptive behaviors that be very distressing to family caregivers. Capturing these in clinical research settings is crucial. Objectives To develop evaluate the psychometric properties of an instrument brief, yet comprehensive, assessing a broad range HD. Methods A pool 30 items encompassing common HD was generated. Items were scored on...
Prior studies have relied on conventional observer-based severity ratings such as the Unified Huntington's Disease Rating Scale (UHDRS) to identify early motor markers of decline in disease (HD).The present study examined predictive utility graphomotor measures handwriting and drawing movements.Seventeen gene-positive premanifest HD subjects underwent comprehensive clinical, cognitive, motor, assessments at baseline follow-up intervals ranging from 9-36 months. Baseline were subjected linear...
Objective: To explore the usefulness of Lowenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) [Crocco et al, 2013], a novel memory-based cognitive stress test capitalizing on semantic interference, in Huntington’s Disease (HD). Participants Methods: 12 healthy adults (HA) 14 individuals with manifest HD were administered LASSI-L as part an annual research visit UCSD Clinical Research Center (HDCRC.) each group well matched regard to age education. Individuals had average...
Objective: To assess the utility of Mini Mental State Exam (MMSE) and Montreal Cognitive Assessment (MoCA) for tracking cognitive changes Huntington’s Disease. Participants Methods: Currently, most frequently used brief assessment global functioning is MMSE. Although MMSE helpful distinguishing individuals without significant impairment from those with dementia, it not particularly sensitive to more subtle deficits. The MoCA another screening tool that has been shown be mild may have greater...
To examine the usefulness of cUHDRS in reflecting disease progression a well-characterized group mild to moderate HD subjects followed at one academic center.