A5014511272- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Lightning and Electromagnetic Phenomena
- Hedgehog Signaling Pathway Studies
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Renal and related cancers
- Advanced Sensor and Energy Harvesting Materials
- Epigenetics and DNA Methylation
- Electrospun Nanofibers in Biomedical Applications
- Aerosol Filtration and Electrostatic Precipitation
- Icing and De-icing Technologies
- Lipid metabolism and biosynthesis
- Surface Modification and Superhydrophobicity
- Marine Invertebrate Physiology and Ecology
Centre for Inflammation Research
2022-2024
University of Edinburgh
2022-2024
Soochow University
2024
Queen's Medical Centre
2022-2023
MRC Centre for Regenerative Medicine
2022-2023
Wuhan University of Science and Technology
2020
Progressive fibrosis is a feature of aging and chronic tissue injury in multiple organs, including the kidney heart. Glioma-associated oncogene 1 expressing (Gli1
Abstract Cells need to rapidly and precisely react multiple mechanical chemical stimuli in order ensure precise context‐dependent responses. This requires dynamic cellular signalling events that homeostasis plasticity when needed. A less well‐understood process is response elevated interstitial fluid pressure, where the cell senses responds changes extracellular hydrostatic pressure. Here, using quantitative label‐free digital holographic imaging, combined with genome editing, biochemical...
The Hippo signalling pathway is a master regulator of cell growth, proliferation, and cancer. transcriptional coregulators the pathway, YAP TAZ, are central in various cancers. However, how TAZ get activated most types cancers not well understood. Here, we show that androgens activate YAP/TAZ via androgen receptor (AR) prostate cancer (PCa), this activation differential. AR regulates translation while inducing transcription encoding gene, WWTR1 . Furthermore, AR-mediated regulated by RhoA...
The Hippo signalling pathway is dysregulated across a wide range of cancer types and, although driver mutations that directly affect the core components are rare, handful found within pleural mesothelioma (PM). PM deadly disease lining lung caused by asbestos exposure. By pooling largest-scale clinical datasets publicly available, we here interrogate associations between most prevalent and disruption in patients, while assessing correlations with variety markers. This analysis reveals...
In this study, polyimide (PI) and polysulfonamide (PSA) were used as base materials, polyethylene glycol (PEG) was added to successfully prepare PI/PSA/PEG nanofiber membranes through electrospinning technology. Subsequently, water etching performed on the membranes, utilizing solubility of PEG form rough wrinkled structure, further enhancing surface hydrophobicity. The experimental results showed that under conditions a spinning voltage 10 kV, PI/PSA mass fraction 15 wt.%, PEG-to-PI/PSA...
The collection efficiency of many electrostatic precipitators (ESPs) must be improved in order to fulfill the particulate emission standard, which has become increasingly rigorous. According classical theory, decreasing gas velocity for an electric field is one most effective methods enhancing efficiency. Thus, we proposed a side-flow ESP, which, compared its conventional counterpart, requires far lower when flow rate constant. First, using aerodynamics, theoretical expression and dust...
Abstract Motivation Disrupted PERCC1 gene expression causes an intractable congenital diarrhoea in infants. However, this gene’s molecular mechanism is unknown and no homologous proteins have been reported. Results Our detailed evolutionary analysis of sequence reveals it to be a previously unappreciated member the YAP/TAZ/FAM181 family transcriptional regulators. Like YAP TAZ, likely interacts with DNA via binding TEA/ATTS domain transcription factors (TEADs) using its conserved interface-2...
ABSTRACT As the core, tumorigenic downstream effectors of Hippo signalling pathway, YAP/TAZ and TEAD family transcription factors represent attractive targets for drug discovery efforts within cancer research. This is particularly true context pleural mesothelioma, in which there are many recent preclinical developments clinical trials evaluating efficacy inhibitors. The range inhibitors have shown great promise, but comparisons their performances so far limited. Here we develop a high...