A5033595579- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Genetic diversity and population structure
- Subterranean biodiversity and taxonomy
- Animal Ecology and Behavior Studies
- Genomics and Phylogenetic Studies
- Parkinson's Disease Mechanisms and Treatments
- Aquatic Invertebrate Ecology and Behavior
- Mollusks and Parasites Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
University of Patras
2019-2024
University of Crete
2012-2017
In this study we investigate the evolutionary relationships of Scolopendra cingulata (Latreille, 1829) within insular Greece. Our main goal is to infer time frame differentiation species in area. regard, sequence data originating from three mitochondrial genes are used reconstruct history 47 populations S. Aegean archipelago. Within phylogenetic framework and by implementing a relaxed molecular clock methodology, estimates separations lineages. The results analysis support presence distinct...
Abstract Background Loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) underlines much pathology Parkinson’s disease (PD), but existence an endogenous neurogenic system that could be targeted as a therapeutic strategy has been controversial. BNN-20 is synthetic, BDNF-mimicking, microneurotrophin we previously showed to exhibit pleiotropic neuroprotective effect on SNpc “weaver” mouse model PD. Here, assessed its potential effects neurogenesis. Methods We quantified...
Albinaria (Gastropoda, Clausiliidae) is a pulmonate genus distributed around the north-eastern coasts of Mediterranean. It most 'speciose' within family Clausiliidae, exhibiting high degree morphological and genetic differentiation, serving as model for several ecological, systematics evolutionary studies. Nevertheless, many aspects remain uncertain mainly due to large number taxa whose classification has not yet been evaluated with solid synapomorphic characters. Thirty-one species are...
Alpha-synuclein plays a pivotal role in Parkinson's disease (PD) pathogenesis, with α-synuclein aggregates/oligomers being identified as toxic species and phosphorylation at Serine 129 promoting aggregation/oligomerization. We investigated the biochemical profile of "weaver" mouse, genetic PD model. Our results revealed increased midbrain, striatum, cortex phase established dopaminergic degeneration on postnatal day 100. These indicate pathology already this stage potential for age-related...