A5113508482- Influenza Virus Research Studies
- Hormonal and reproductive studies
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Bacterial Infections and Vaccines
- Prostate Cancer Treatment and Research
- Bacterial Genetics and Biotechnology
- Travel-related health issues
- Regulation of Appetite and Obesity
- Metabolism and Genetic Disorders
- melanin and skin pigmentation
- Sperm and Testicular Function
- Circadian rhythm and melatonin
- Diabetes and associated disorders
- Pharmacological Effects and Assays
- Nasal Surgery and Airway Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Veterinary medicine and infectious diseases
- vaccines and immunoinformatics approaches
- Allergic Rhinitis and Sensitization
- Neuropeptides and Animal Physiology
- Renin-Angiotensin System Studies
- Hypothalamic control of reproductive hormones
- Adrenal Hormones and Disorders
- Lymphoma Diagnosis and Treatment
National Research Council Canada
2025
Université Laval
1986-2024
NEOMED Institute
2015
GlaxoSmithKline (United Kingdom)
2011
GlaxoSmithKline (Canada)
2008-2011
Smiths Detection (Canada)
2008
Dana-Farber Cancer Institute
2005
Centre de Géomatique du Québec
2004
Centre hospitalier universitaire de Québec
1999
Centre National de la Recherche Scientifique
1992-1994
The neuraminidase inhibitor oseltamivir is currently used for treatment of patients infected with the pandemic A/H1N1 (pH1N1) influenza virus, although drug-resistant mutants can emerge rapidly and possibly be transmitted. We describe characteristics a pair oseltamivir-resistant oseltamivir-susceptible pH1N1 clinical isolates that differed by single change (H274Y) in protein. Viral fitness was assessed vitro determining replication kinetics MDCK alpha2,6 cells vivo performing experimental...
We assessed whether peripheral activation of microglia by a nasal proteosome-based adjuvant (Protollin) that has been given safely to humans can prevent amyloid deposition in young mice and affect memory function old with large load.Amyloid precursor protein (APP) transgenic (Tg) J20 received treatment Protollin weekly for 8 months beginning at age 5 months. Twenty-four-month-old were treated 6 weeks.We found reduction the level fibrillar (93%), insoluble beta-amyloid (Abeta; 68%), soluble...
Influenza A/H3N2 viruses have caused the most severe epidemics since 1968 despite current immunization programs with inactivated vaccines. We undertook a side-by-side preclinical evaluation of different adjuvants (Alum, AS03, and Protollin) routes administration (intramuscular [i.m.] intranasal [i.n.]) for assessing their effect on immunogenicity cross-reactivity split vaccines (A/H3N2/New York/55/2004). Humoral T cell-mediated immune responses against homologous virus heterologous drifted...
Nasal immunization was studied to determine if it could elicit an immune response capable of preventing vaginal colonization by Neisseria gonorrhoeae or reducing its duration in the estradiol-treated mouse model. administration gonococcal outer membrane (OM) preparations induced development systemic and responses that were directed mainly against a limited number OM proteins. The impact nasal on N. evaluated use experimental model, which mice treated with estradiol prolong infection....
This study presents an automated digital microfluidic platform capable of simultaneously detecting SARS-CoV-2 infection (spike protein) and immune response markers (IgG IgA) in saliva with high sensitivity specificity.
The cross-bactericidal and cross-protective activities of a monoclonal antibody (MAb) named Me-7, which is directed against an antigenically highly conserved epitope on the meningococcal NspA protein, were studied. This MAb efficiently killed in vitro, presence rabbit or human serum, 13 14 strains tested, including 9 9, 2 3, serotypes B, A, C, respectively. Me-7 also significantly reduced by more than 75% levels bacteremia recorded for mice challenged with 10 11 tested. Analysis predicted...
ABSTRACT A low-molecular-weight protein named NspA (neisserial surface A) was recently identified in the outer membrane of all Neisseria meningitidis strains tested. Antibodies directed against this were shown to protect mice an experimental meningococcal infection. Hybridization experiments clearly demonstrated that nspA gene also present genomes 15 gonorrhoeae Cloning and sequencing N. B2 revealed open reading frame 525 nucleotides coding for a polypeptide 174 amino acid residues, with...
The leporidae (rabbit and hare) pituitary intermediate lobe (IL) differs from that of other mammals by its neuroendocrine regulation. In particular, it is not submitted to the classic dopaminergic inhibitory control, which has been considered as a repressive factor for expression glucocorticoid receptors (GR) in mammalian IL. Hence, present experiments aimed at examining rabbit IL possible existence GR. Using both immunocytochemistry binding studies with (3H)-dexamethasone, we localized GR...
Le présent article documente les situations d’exclusion qui peuvent compromettre la participation sociale des jeunes adultes LGBTQ2S au sein organisations vouées à diversité sexuelle et pluralité genres Québec. Quarante-neuf entrevues individuelles par récit de vie ont été réalisées avec personnes 18 29 ans dans le cadre du Partenariat recherche SAVIE-LGBTQ. L’analyse thématique données qualitatives a permis dégager quatre barrières. Les barrières correspondent enjeux personnels vécus propos...