A5044984821- Cancer, Stress, Anesthesia, and Immune Response
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Immune cells in cancer
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Pluripotent Stem Cells Research
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- RNA modifications and cancer
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2022-2023
University of Naples Federico II
2021
While HCC is an inflammation-associated cancer, CRLM develops on permissive healthy liver microenvironment. To evaluate the immune aspects of these two different environments, peripheral blood-(PB), peritumoral-(PT) and tumoral tissues-(TT) from patients were evaluated.
Abstract Lin28 is an evolutionary conserved RNA-binding protein that plays important roles during embryonic development and tumorigenesis. It regulates gene expression through two different post-transcriptional mechanisms. The first one based on the regulation of miRNA biogenesis, in particular let-7 family, whose suppressed by Lin28. Thus, loss leads to upregulation mRNAs are targets species. second mechanism direct interaction with a large number mRNAs, which results their translation....
Abstract Background and purpose: HCC is inflammation-associated cancer develops on chronic inflamed liver while CRLM develop permissive healthy microenvironment. To evaluate the immune aspects of these two different environments, peripheral blood-(PB), peritumoral-(PT) tumoral tissues-(TT) from patients were evaluated. Methods: 40 34 enrolled freshly TT, PT PB collected at surgery. PB-, PT- TT-derived CD4 + CD25 Tregs PB-derived − Teffector cells (Teffs) isolated characterized for phenotype...
Metastatic disease in tumors originating from the gastrointestinal tract can exhibit varying degrees of tumor burden at presentation. Some patients follow a less aggressive course, characterized by limited number metastatic sites, referred to as "oligo-metastatic disease" (OMD). The precise biological characteristics that define oligometastatic behavior remain uncertain. In this study, we present protocol designed prospectively identify OMD, with aim proposing novel therapeutic approaches...
Abstract Background: Hepatocellular carcinoma (HCC) and colorectal cancer liver metastasis (CRLM) represent the two most occurring cancer. Aim of project was to analyze impact TME on HCC versus CRLM. In particular, Tregs were evaluated in tumor (TT), peritumoral (PT) tissue peripheral blood (PB) identify immune mechanisms therapeutic targets. Methods: characterized PB/PT/TT cell suspension from 40 34 CRLM by flow cytometry (FOXP3, CD25, CD4, CD45RA, CTLA-4, CXCR4, PD-1, ICOS ENTPD1). PB-,...