A5010277441- RNA Research and Splicing
- RNA modifications and cancer
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Autophagy in Disease and Therapy
- Genomics and Chromatin Dynamics
Whitehead Institute for Biomedical Research
2022-2025
University of Udine
2023-2025
Abstract Insulin receptor (IR) signaling is central to normal metabolic control and dysregulated in diseases such as type 2 diabetes. We report here that IR incorporated into dynamic clusters at the plasma membrane, cytoplasm nucleus of human hepatocytes adipocytes. stimulation promotes further incorporation these insulin-sensitive cells but not insulin-resistant cells, where both accumulation behavior are reduced. Treatment with metformin, a first-line drug used treat diabetes, can rescue...
Biomolecular condensates are membraneless compartments that organize biochemical processes in cells. In contrast to well-understood mechanisms describing how form and dissolve, the principles underlying condensate patterning - including their size, number spacing cell remain largely unknown. We hypothesized RNA, a key regulator of formation dissolution, influences patterning. Using nucleolar fibrillar centers (FCs) as model condensate, we found inhibiting ribosomal RNA synthesis...
Abstract APE1 [apurinic/apyrimidinic (AP) endodeoxyribonuclease 1] is the main endonuclease of base excision repair pathway acting on abasic sites in DNA. an abundant nuclear protein, and improper expression or localization this factor could lead to accumulation toxic DNA intermediates. Altered subcellular distribution are associated with cancer development, suggesting importance a fine-tuning mechanism for activities. Recent works highlighted presence within nucleoli cells ability form...
Abstract APE1 (apurinic/apyrimidinic endodeoxyribonuclease 1) is the main endonuclease of base excision repair (BER) pathway acting on abasic (AP)-sites in damaged DNA. an abundant nuclear protein with a higher concentration than other BER enzymes, and therefore, improper expression localization this factor could lead to accumulation toxic DNA intermediates. Altered sub-cellular localization, levels, or hyper-acetylation are associated cancer development suggesting importance fine-tuning...