A5088324966- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Cellular Mechanics and Interactions
- Lung Cancer Treatments and Mutations
- Histiocytic Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Viral-associated cancers and disorders
- Erythrocyte Function and Pathophysiology
- HER2/EGFR in Cancer Research
- Eosinophilic Disorders and Syndromes
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
Soochow University
2024
Tungs' Taichung MetroHarbor Hospital
2013
Fox Chase Cancer Center
2012
The University of Texas MD Anderson Cancer Center
2012
University of Nevada, Reno
2012
National Defense Medical Center
2006-2009
Tri-Service General Hospital
2006-2009
Extracellular matrix metalloproteinase inducer (EMMPRIN) and the type II transmembrane serine protease, matriptase, are expressed in several human cancers play an important role tumor progression. The aim of present study was to investigate immuno-staining patterns EMMPRIN matriptase patients with esophageal squamous cell carcinomas (SCC) correlate percentage staining differentiation clinical parameters. immunoreactivity seen on membrane cytoplasm cells all 41 cases SCC evaluated. 48 +/- 3%...
Cortactin, fascin, and survivin have been documented in several human cancers play important roles tumor progression. We collected 57 surgical specimens, including esophageal squamous cell carcinomas (SqCC; 7 well-differentiated, 15 moderately differentiated, 24 poorly differentiated), 3 dysplasias, 8 normal tissues. Tissue microarrays were constructed the immunostaining scores for cortactin, assessed. In 46 SqCC we examined relationship between expression of three biomarkers differentiation...
To determine whether higher expression of fascin, an actin-bundling protein associated with motility, in conventional renal cell carcinoma (RCC) is more advanced stages the disease.Immunohistochemical analysis fascin was performed tissue microarrays 108 RCCs including 55 clear (CRCCs), 39 CRCCs granular differentiation (GRCCs), 8 sarcomatoid (SRCCs) and 6 metastatic RCCs.The undetectable normal tubules all control cases. However, among RCC cases, immunoreactivity seen on membrane cytoplasm....
The effects of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, have not been studied in esophageal squamous cell cancer (ESCC). Cell viability assay; flow cytometry for cycle and annexin V apoptosis assays; assays migration, invasion, adhesion to extracellular matrix (ECM); immunoblotting immunofluorescence staining were performed three ESCC lines. Tumor xenograft with semiquantitative immunohistochemistry was used study the SAHA vivo. effectively inhibited growth...
BackgroundFollicular dendritic cell sarcoma (FDCS) represents an exceedingly rare malignant neoplasm. Inflammatory pseudotumor-like follicular (IPT-like FDCS) is recognized as a variant manifestation of FDCS. The clinical incidence this particular disease remarkably low, resulting in the absence established standardized protocols for its management and treatment.MethodsPresented here case primary Epstein-Barr virus (EBV)-positive splenic IPT-like FDCS, noteworthy manifesting thrombocytopenia...
Abstract Background: Genetic abnormalities in the anaplastic lymphoma kinase (ALK) gene result activation of signaling pathways including Akt, mTor, and JAK/Stat3. ALK has been shown to be a primary oncogenic driver variety human tumors, both hematologic malignancies such as large cell lymphoma, well solid tumors neuroblastoma, non-small lung cancer, myofibroblastic most recently, high grade serous ovarian carcinoma. While only ∼3% all breast cancers have reported genetic abnormalities, our...