A5031752046- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Corneal Surgery and Treatments
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- Neurological Disorders and Treatments
- RNA modifications and cancer
- Connexins and lens biology
- Drug-Induced Ocular Toxicity
- Glaucoma and retinal disorders
- Inflammasome and immune disorders
- Peroxisome Proliferator-Activated Receptors
- Ocular Surface and Contact Lens
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nitric Oxide and Endothelin Effects
- FOXO transcription factor regulation
- Retinal Development and Disorders
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Calpain Protease Function and Regulation
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
Shandong Provincial Hospital
2024
National Institutes of Health
2006-2014
National Eye Institute
2014
Abstract Puerarin (Pue) has significant antioxidant and anti‐inflammatory properties. This work was designed to clarify investigate the potential mechanisms of Pue in atherosclerosis (AS) progression. In vivo, acrolein (Acr) inhaled through drinking water construct AS model. vitro, CCK‐8 assay lactate dehydrogenase (LDH) kit were used detect cell viability. Apoptosis detected by flow cytometry. The content malondialdehyde (MDA) determined commercial kit, level inflammatory factors ELISA,...
Purpose.: We developed a novel technique for accelerated drug screening and retinotoxin characterization using time-lapse optical coherence tomography (OCT) microapplication device. Methods.: Using an ex vivo rabbit eyecup preparation, we studied effects in real-time by microperfusing small retinal areas under transparent fluoropolymer tube. Known retinotoxic agents were applied to the retina 5-minute periods, while changes structure, thickness, reflectance monitored with OCT. The OCT images...
Atherosclerosis (AS) is a common pathogenesis of cardiovascular diseases. Puerarin (Pue) Chinese herbal remedy used to prevent and treat AS. Here, this research investigated the effect Pue on AS progression. ApoE−/− mice were induced with acrolein. Body weight, blood lipid index, inflammatory factors, mitochondrial oxidative stress, deposition detected. IL-6 TNF-α detected by ELISA. Oil red staining H&E observe aortic sinus plaque lesions. Serum expressions factors IL-6, TNF-a, SOD, GSH MDA...