A5009611889- Advanced Polymer Synthesis and Characterization
- Surfactants and Colloidal Systems
- Block Copolymer Self-Assembly
- Advancements in Transdermal Drug Delivery
- Essential Oils and Antimicrobial Activity
- Photosynthetic Processes and Mechanisms
- Hemoglobin structure and function
- Pickering emulsions and particle stabilization
- Porphyrin Metabolism and Disorders
- Olfactory and Sensory Function Studies
- Mass Spectrometry Techniques and Applications
- Lipid Membrane Structure and Behavior
- Plant Pathogens and Fungal Diseases
- Inhalation and Respiratory Drug Delivery
- Chemical Reactions and Isotopes
- Plant Pathogens and Resistance
- Bacterial Genetics and Biotechnology
- Dermatology and Skin Diseases
- Drug Solubulity and Delivery Systems
- Polymer Nanocomposites and Properties
- Anaerobic Digestion and Biogas Production
- Iron Metabolism and Disorders
- Plant and fungal interactions
- Zeolite Catalysis and Synthesis
- Advanced Drug Delivery Systems
Lund University
1993-2007
Aarhus University
2006
University at Buffalo, State University of New York
1998-2000
Graduate School Experimental Plant Sciences
1986
Summary Haem A, a prosthetic group of many respiratory oxidases, is probably synthesized from haem B (protohaem IX) in pathway which O an intermediate. Possible roles the Bacillus subtilis ctaA and CtaB gene products A synthesis were studied. Escherichia coli does not contain A. The CtaA on plasmids E. resulted accumulation membranes. presence together with increased amount found coli. was detected wild‐type B. strains. previously isolated deletion mutant to O, but ctaB mutants constructed...
The phase behavior and microstructure at 25 °C in mixtures of the amphiphilic block copolymer Pluronic P104 (with formula (EO)27(PO)61(EO)27, where EO is ethylene oxide PO propylene oxide), D2O, p-xylene are presented. A rich with both normal ("oil-in-water") reverse ("water-in-oil") phases observed. Two isotropic micellar solutions (normal solutions) six lyotropic liquid crystalline cubic, hexagonal, bicontinuous lamellar phases) formed. structural length scales were determined from...
Poly(ethylene oxide)−poly(propylene oxide)−poly(ethylene oxide) (PEO−PPO−PEO) block copolymers, commercially available as Poloxamers or Pluronics, are unique in forming ordered cubic phases consisting of reverse (water-in-oil) micelles. We set out to study the microstructure (form and dimension) micelles order (from a micellar solution lattice) with increasing copolymer volume fraction molecular weight. The technique we used was small-angle neutron scattering (SANS) solvent contrast...
Two isothermal (25 °C) phase diagrams with the block copolymer (EO)43(PO)16(EO)43 and (EO)5(PO)68(EO)5, respectively, in water p-xylene are presented (EO is ethylene oxide PO propylene oxide). The copolymers have approximately same molecular weight, albeit unbalanced PEO/PPO ratio. amounts relative proportions of solvents can modulate resulting microstructures, although sequence observed depends on rich EO forms predominantly normal (oil-in-water) structures while reverse (water-in-oil) structures.
Heme A is a prosthetic group of many respiratory oxidases. It synthesized from protoheme IX (heme B) seemingly with heme O as stable intermediate. The Bacillus subtilis ctaA and ctaB genes are required for synthesis, respectively (B. Svensson, M. Lübben, L. Hederstedt, Mol. Microbiol. 10:193-201, 1993). Tentatively, CtaA involved in the monooxygenation oxidation methyl side on porphyrin ring D synthesis B. plasmids both Escherichia coli were found to result novel membrane-bound...
Synthesis of heme A from B (protoheme IX) most likely occurs in two steps with O as an intermediate. Bacillus subtilis CtaB, integral membrane protein, functions farnesylation to form O. CtaA, also a is required for synthesis and appears be monooxygenase and/or dehydrogenase. Wild‐type ctaA ctaB expressed together plasmids B. resulted CtaA containing equimolar amounts low‐spin A; this was named cyt ba ‐CTA. mutant gene identified characterised. It encodes truncated CtaB polypeptide. the on...
The phase behavior of the (EO)19(PO)43(EO)19/p-xylene system (where EO is ethylene oxide and PO propylene oxide) with temperature discussed. In this block copolymer end blocks are crystallizable, middle noncrystallizable. Several techniques were used to delineate boundaries (SAXS, WAXS, 1H NMR, 2H DSC). An anisotropic region a lamellar structure semicrystalline PEO domains amorphous PPO formed at low temperatures high concentrations. has one-dimensional swelling increasing p-xylene...
Formulations for nasal drug delivery often rely on water sorption to adhere the mucosa, which also causes a higher gradient over tissue and subsequent dehydration. The primary aim of this study was therefore evaluate mucosal response dehydration resolve hypothesis that mucoadhesion achieved through could be constraint absorption via route. effect altering activity vehicle Xylometazoline HCl 51Cr-EDTA uptake studied separately ex vivo using flow diffusion cells excised porcine mucosa. We have...
Reverse micelle formation of the poly(ethylene oxide)/poly(propylene oxide) block-copolymer (EO)13(PO)30(EO)13 (L64) in p-xylene was investigated as a function water content and copolymer content, using small-angle neutron scattering (SANS). PEO/PPO block-copolymers are generally soluble xylene but without forming aggregates. However, effective block segregation increases dramatically upon addition small amounts water, micelles form. The SANS data were analyzed an absolute scale model...
The aim of this study was to demonstrate that penetration quercetin, hydrogen peroxide and ascorbic acid through skin membranes can be monitored amperometrically. Skin membrane fixed on the top chemically modified electrodes appropriate compound registered as electrode current. methodology allows from solution well pharmaceutical creams. From real-time measurements current, fluxes diffusion coefficients mentioned compounds in have been estimated.