A5004329705- Ginseng Biological Effects and Applications
- Hops Chemistry and Applications
- Gut microbiota and health
- Zoonotic diseases and public health
- Nutrition, Genetics, and Disease
- Alcohol Consumption and Health Effects
- Inflammatory Bowel Disease
- Cancer-related molecular mechanisms research
- Probiotics and Fermented Foods
- Fermentation and Sensory Analysis
- Race, Genetics, and Society
Oregon State University
2022-2025
Parkland College
2012
Xanthohumol (XN), a polyphenol found in the hop plant (Humulus lupulus), has antioxidant, anti-inflammatory, prebiotic, and anti-hyperlipidemic activity. Preclinical evidence suggests gut microbiome is essential mediating these bioactivities; however, relatively little known about XN's impact on human microbiota vivo. We conducted randomized, triple-blinded, placebo-controlled clinical trial (ClinicalTrials.gov NCT03735420) to determine safety tolerability of XN healthy adults. Thirty...
The slow pace of discovery bioactive natural products can be attributed to the difficulty in rapidly identifying them complex mixtures such as plant extracts. To overcome these hurdles, we explored utility two machine learning techniques, i.e., Elastic Net and Random Forests, for individual anti-inflammatory principle(s) an extract inflorescences hops (Humulus lupulus) containing hundreds products. We fractionated a hop by column chromatography obtain 40 impure fractions, determined their...